Methadone
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QT interval prolongation and bradycardia in a neonate following in utero exposure: case report A female neonate experienced QT interval prolongation and bradycardia at birth after exposure to methadone in utero. The 21-year-old mother of the neonate had a history of heroin abuse and had been receiving methadone 50 mg/day [duration of treatment not stated] as maintenance therapy. The neonate was spontaneously delivered at term and was noted to be bradycardic (heart rate 80–90 beats/min). An ECG revealed a corrected QT interval (QTc) of 510ms in the neonate, although the QTc was normal in the mother. It was postulated the prolonged QTc in the neonate was due to in utero exposure to methadone. The neonate underwent continuous ECG monitoring which demonstrated a progressive shortening of the QTc. She experienced mild withdrawal symptoms which were managed with supportive care. On day 5 her QTc was 380ms and her heart rate was 120–140 beats/min, so she was discharged. She continued to be well with a normal QTc during follow-up at age 2 months. hussain t, et al. Maternal methadone may cause arrhythmias in neonates. Acta 801071966 Paediatrica 96: 768-769, No. 5, May 2007 - United Kingdom
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Reactions 14 Jul 2007 No. 1160
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