Methods of External Hyperthermic Heating

The development of equipment capable of producing and monitoring safe, effective and predictable hyperthermia treatments represents a major challenge. The main problem associated with any heating technique is the need to adjust and control the distributio

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M. Gautherie (Ed.)

Methods of External Hyperthermic Heating With Contributions by 1. W. Hand . K. Hynynen . P. N. Shrivastava . T. K. Saylor With 121 Figures and 34 Tables

Springer-Verlag Berlin Heidelberg New York London Paris Tokyo HongKong

Dr. Michel Gautherie Laboratoire de Thermologie Biomedicale Universite Louis Pasteur Institut National de la Sante et de la Recherche Medicale 11, rue Humann 67085 Strasbourg Cedex, France

ISBN-13:978-3-642-74635-2 DOl: 10.1007/978-3-642-74633-8

e-ISBN-13:97S-3-642-74633-S

Library of Congress Cataloging-in-Publication Data Methods of external hyperthermic heating / M. Gautherie (ed.); with contributions by J. W. Hand ... let aI.l. p. cm. - (Clinical thermology. Subseries thermotherapy) Includes bibliographical references. ISBN-13:978-3-642-74635-2 (V. S.) 1. Thermotherapy. I. (]autherie, Michel. II. Series. RM865.M48 1990 615.8'32 - dc20 89-21981 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9, 1965, in its version of June 24, 1985, and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law.

© Springer-Verlag Berlin Heidelberg 1990 Softcover reprint of the hardcover 1st edition 1990 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product Liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. lYPesetting: K +V Fotosatz GmbH, Beerfelden 2127/3145-543210 - Printed on acid-free paper

Preface

The development of equipment capable of producing and monitoring safe, effective and predictable hyperthermia treatments represents a major challenge. The main problem associated with any heating technique is the need to adjust and control the distribution of absorbed power in the tissue during treatment. Power distribution is considered adequate only when tumor tissue can be maintained at the required hyperthermic levels while, at the same time, healthy tissue is not overheated. This problem is particularly crucial when external heating devices are used to produce hyperthermia. External hyperthermia refers to those methods which supply heat to tumor tissue in an external, noninvasive manner, as opposed to internal hyperthermia by which heat is supplied to tumor tissue in situ. Until recently, most of the technical developments and clinical trials of thermotherapy