Methods of Production the Isotope 67 Cu
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ods of Production the Isotope 67Cu G. H. Hovhannisyana, *, A. V. Stepanyana, E. R. Saryana, and L. A. Amirakyana aYerevan
State University, Yerevan, Armenia *e-mail: [email protected]
Received December 16, 2019; revised February 1, 2020; accepted February 10, 2020
Abstract—The nuclear reactions on zinc isotopes leading to the formation of the medical theranostic isotope 67Cu have been investigated. Model calculations were made using the TALYS1.9 code. The results are compared with the published experimental data. The comparison of calculated and experimental data showed a satisfactory agreement in the case of the proton-nuclear reactions. In the case of the calculations of the photonuclear reactions, the essential differences are observed at the maximums of the excitation functions. The calculated data in the case of the (γ, n) reactions do not reveal the widths and structure of the excitation functions. Keywords: photonuclear reactions, TALYS 1.9, radioisotope,67Cu DOI: 10.3103/S106833722003010X
1.INTRODUCTION The radioisotopes play an important role in many fields, from medical applications to national security and basic research. Today, the radionuclide research and treatment methods are widely used in various fields of scientific and practical medicine – in oncology, cardiology, hepatology, urology and nephrology, pulmonology, endocrinology, traumatology, neurology and neurosurgery, pediatrics, allergology, hematology, clinical immunology, and etc. [1]. Not surprisingly, the radioisotope production technologies are developed gradually. The isotopes are the part of radiopharmaceuticals (RP), which are introduced into the human body. An important task is to obtain such RPs that will give the expected result at low doses and do little harm to the human body. To this end, the scientists are exploring new radioisotopes and methods for their preparation. From the point of view of their scope, the radioisotopes for nuclear medicine and the corresponding RP based on them are classified as the diagnostic and therapeutic. The radiation therapy is based on the destructive effects of radiation to destroy unwanted cells and tissues in the biological system and is used, in particular, to fight cancer. From a therapeutic point of view, the β-emitting nuclides with the corresponding energy and half-life, such as 186Re and 188Re 131I, 32P, 90Sr, and 90Y are of interest [2]. For diagnostic purposes, the gamma emitters (99mTc, 111In, 123I) are used, either the positron emitters (18F, 11C, 68Ga) [3]. The 67Cu isotope has radiological characteristics, because of which the interest in it has recently increased. The 67Cu emits β-particles with an average energy of 141 keV, and is also an intense gamma emitter (Еγ = 91.266 keV, 7%; 93.311 keV, 16.1%; 184.577 keV, 48.7%). The range of 67Cu β-particles in the tissue is of the same order as the cell diameter [4], while its half-life (Т1/2 = 2.576 days) provides a moderate dose and a long therapeutic effect [5]. The gamma radiation emitted by the radionuclide can be used for diagnostic i
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