• PDF / 169,749 Bytes
• 1 Pages / 595.245 x 841.846 pts (A4) Page_size
• 13 Downloads / 178 Views

DOWNLOAD

REPORT

---

1 OS

Methyl-salicylate/paracetamol Various toxicities: 2 case reports

In a case series, an 8-year-old girl developed dyspnoea, cinchonism, tinnitus, deafness, fever, tachycardia, hyperventilation, anion gap acidosis and eventually died due to methyl-salicylate toxicity secondary to accidental ingestion of methyl-salicylate in an overdose, while a 78-year-old woman developed anion gap metabolic acidosis during treatment with paracetamol [dosages and durations of treatments to reactions onsets not stated; not all routes and outcomes stated]. Case 3: The 8-year-old girl developed dyspnoea and cinchonism (tinnitus and deafness), following ingestion of a mint-like solution, which she found in her house. Additionally, fever, hyperventilation, tachycardia and anion gap acidosis were also evident at the time of admission to a hospital. A ferric chloride test of urine and spinal fluid showed a deep purple colour. The mint-like solution, which she drank was found to be methyl-salicylate [Wintergreen-oil]. A diagnosis of methyl-salicylate toxicity due to accidental ingestion of methyl-salicylate in an overdose was thus established. She eventually died due to the methyl-salicylate toxicity. Case 7: The woman was admitted for severe decubitus ulcers treatment, where she had been receiving wound care and daily doses of paracetamol [acetaminophen]. Subsequently, she developed an anion gap metabolic acidosis with negative lactate and keto acids. Subsequent urine analysis showed elevated level of 5-oxoproline. The anion gap metabolic acidosis was suspected to be due to paracetamol. Seifter JL. Anion-gap metabolic acidemia: case-based analyses. European Journal of Clinical Nutrition 74 (Suppl. 1): 83-86, Aug 2020. Available from: URL: http:// doi.org/10.1038/s41430-020-0685-5

0114-9954/20/1824-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved

803505002

Reactions 3 Oct 2020 No. 1824