Methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms among Greek women with medical history of recurrent preg
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CORRESPONDENCE
Methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms among Greek women with medical history of recurrent pregnancy loss Elias E. Mazokopakis1,2 · Maria G. Papadomanolaki3 Received: 30 October 2019 / Accepted: 26 February 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Keywords MTHFR C677T · MTHFR A1298C · Recurrent pregnancy loss Dear Editor, We read with great interest the article by Ahangari et al. [1] about the association between hereditary thrombophilia genetic variants and recurrent miscarriage among Iranian women. With this letter, we would like to present unpublished relevant results from a study conducted among 383 Greek adults (199 men and 184 women) with low serum folate levels (T nucleotide change increases the RPL risk fourfold (χ2 = 5.8114, OR 4.0899, 95% confidence interval 1.1332–14.7609, p = 0.0159). According to our results, women with RPL should be further investigated for the existence of MTHFR C677T gene polymorphism, without overlooking other strong thrombophilic gene polymorphisms related with RPL. Moreover, this investigation will help the physician to determine the appropriate folate supplement (folic acid or folinic acid or 5-MTHF) which is required for pregnant women, so as to avoid the formation and excess of dangerous unmetabolized folic acid (UMFA) levels in the peripheral circulation [2–4].
* Elias E. Mazokopakis [email protected] 1
Department of Internal Medicine, Naval Hospital of Crete, 73200 Souda, Chania, Crete, Greece
2
Private Medical Office of Internal Medicine, 36 K. Mitsotaki Street, 73132 Chania, Crete, Greece
3
School of Production Engineering and Management, Technical University of Crete, Chania, Crete, Greece
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Table 1 Prevalence and associations of MTHFR gene polymorphisms and allele frequencies among RPL and non-RPL women
Archives of Gynecology and Obstetrics Genotypes MTHFR C667T Normal (CC) Heterozygous (CT) Homozygous (TT) C allele T allele TT + CT vs CC TT vs CT + CC TT vs CT TT vs CC MTHFR A1298C Normal (AA) Heterozygous (AC) Homozygous (CC) A allele C allele
Total women (n = 184)
RPL women (n = 17)
Non-RPL women (n = 167)
p value
32 (17.4%) 97 (52.7%) 55 (29.9%) 161 (43.75%*) 207 (56.25%*)
1 (5.9%) 4 (23.5%) 12 (70.6%) 6 (17.65%*) 28 (82.35%*)
31 (18.6%) 93 (55.7%) 43 (25.7%) 155 (46.41%*) 179 (53.59%*)
0.0006**
125 (67.9%) 52 (28.3%) 7 (3.8%) 302 (82.07%*) 66 (17.93%*)
15 (88.2%) 1 (5.9%) 1 (5.9%) 31 (91.18%*) 3 (8.82%*)
110 (65.9%) 51 (30.5%) 6 (3.6%) 271 (81.14%*) 63 (18.86%*)
0.0013** 0.19** 0.00012** 0.0006** 0.018** 0.097**
0.146**
The data are presented as the number of individuals (percentages) and p
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