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Various toxicities: 7 case reports. In a retrospective cohort study of 440 patients, 7 patients [ages and sexes not stated] were described, who developed Exserohilum rostratum fungal infection following injection of methylprednisolone, which was found to be contaminated with Exserohilum rostratum. Additionally, the patients exhibited severe cognitive dysfunction, required long-term care facilities (LTCF), unable to walk, osteoarticular infection, relapsed meningitis or relapsed osteomyelitis. All the patients received methylprednisolone acetate [dosages, routes and indications not stated]. Subsequently, all the patients developed Exserohilum rostratum fungal infection. It was later revealed that the methylprednisolone acetate injections were contaminated. One of these patients recovered completely after 6 months of the infection, and another patient required LTCF. Of the remaining 5 patients, 1 patient showed relapse of the meningitis, another patient who had asymptomatic meningitis, also showed relapse with lumbar vertebral osteomyelitis. Rest of the patients developed complications, manifested as severe cognitive dysfunction (n=1), unable to walk (n=1) and osteoarticular infection involving hip and shoulder (n=1). All the patients were treated with unspecified antifungal agents [durations of treatments to reactions onsets and outcomes not stated]. Malani AN, et al. Long-term Outcomes of Patients with Fungal Infections Associated with Contaminated Methylprednisolone Injections. Open Forum Infectious Diseases 7: 803508270 ofaa164, No. 6, 9 May 2020. Available from: URL: http://doi.org/10.1093/ofid/ofaa164

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Reactions 17 Oct 2020 No. 1826