Micellar characteristics of an amphiphilic star-block copolymer in DES-water mixture
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ORIGINAL CONTRIBUTION
Micellar characteristics of an amphiphilic star-block copolymer in DES-water mixture Pooja Patidar 1 & Bharatkumar Kanoje 2 & Anita Bahadur 1 & Ketan Kuperkar 2 & Debes Ray 3 & Vinod K. Aswal 3 & Murong Wang 4 & Li-Jen Chen 4 & Pratap Bahadur 5 Received: 5 November 2019 / Revised: 5 September 2020 / Accepted: 12 October 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Deep eutectic solvents (DES) have revealed the ability to promote the aggregation of amphiphiles in solution. With a brief overview on the self-assembly of amphiphilic substances in protic/aprotic, polar/non-polar solvents, ionic liquids (ILs), and deep eutectic solvents, we herein report the aggregation behavior of a star block (4-arm) ethylene oxide (EO)-propylene oxide (PO) block copolymer (5 %w/v) tetronic T1304 in the presence of different DESs [ChCl: urea, ChCl: ethylene glycol (EG), ChCl: glycerol (Gly), ChCl: malonic acid (MA), ChCl: glutaric acid (GA), and ChCl: oxalic acid (OA)] in varying aqueous molar ratio solution. From high-sensitivity differential scanning calorimetry (HSDSC), surface tension (S.T.), small-angle neutron scattering (SANS), and dynamic light scattering (DLS), we present for the first time the self-aggregation and size distribution profile of amphiphilic tetronic T1304 in DES-water mixture system. The solubility of poorly water-soluble drug, quercetin (QN), was also checked in 5 %w/v copolymeric micelles and in presence of different DESs using UV-Visible spectroscopy. The presence of various DESs alter the micellization and micellar characteristics and such observed behavior are due to the favorable interactions that support the selfassembly in DES-water solvent mixture which is further elucidated by the molecular simulation study using the Gauss View 5.0.9.
Keywords Block copolymer . Deep eutectic solvents (DESs) . Critical micelle concentration (CMC) . Thermodynamics, aggregation . Simulation . Drug solubilization
Highlights • The cloud point (CP) and the micellar parameters of amphiphilic EO-PO copolymer in water and in different DES-water are reported. • The presence of DES generally decreased CP and favored micellization and showed enhanced solubility of the drug quercetin (QN). • The data on CMT (from HSDSC), Dh (from DLS), and Nagg (from SANS) are reported and discussed. • The favorable interaction in the examined systems is well elucidated using computational study. * Ketan Kuperkar [email protected] 1
Department of Zoology, Sir PT Sarvajanik College of Science, Surat 395001, India
2
Department of Applied Chemistry, Sardar Vallabhbhai National Institute of Technology, Surat 395007, India
3
Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai 400085, India
4
National Taiwan University, Taipei 10617, Taiwan
5
Department of Chemistry, Veer Narmad South Gujarat University, Surat 395007, India
Introduction Nano-scale core-shell micellar architecture or aggregation in an aqueous amphiphilic system is a natural phenomenon governed by the n
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