Microvascular alterations in children with optic disk drusen evaluated by optical coherence tomography angiography
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PEDIATRICS
Microvascular alterations in children with optic disk drusen evaluated by optical coherence tomography angiography María Alarcón-Tomas 1
&
Bachar Kudsieh 1,2 & Esther Casado Lopez-Franca 1 & Yael Cohen 1 & José M. Ruiz-Moreno 1,3
Received: 14 June 2020 / Revised: 23 September 2020 / Accepted: 5 October 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose To asses changes in vessel density (VD) in children with optic disk drusen (ODD) using swept source optical coherence tomography angiography (OCTA). Methods Cross-sectional study of 27 eyes with ODD compared with age-matched controls. Peripapillary and macular VD were measured in the superficial retinal capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC). The correlation between VD changes with alterations in retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and visual field (VF) was analyzed. Results Mean participant age was 12.5 ± 3.3 years (range, 7–18 years); 63% was females. In the patients vs. controls, median central peripapillary VD was 52.9% vs. 50.6% (p = 0.63) for SCP; 48.1% vs. 53.8% (p = 0.017) for DCP; and 17.0% vs. 28.2% (p = 0.0037) for CC, respectively. VD in the superior and nasal CC layers was significantly lower in the patients (36.3% vs. 56.2%; p < 0.001) and (60.4% vs. 70.3%, p < 0.001), respectively. No significant differences were observed for VD in the macular region. The RNFL was thinner in eyes with superficial drusen versus controls (87 vs. 111 μm; p < 0.001). No significant differences between were observed in GCL thickness (p = 0.13). Nasal SCP and nasal RNFL VD were moderately correlated (r = 0.54, p < 0.01), while mean VF deviation was strongly correlated with median SCP VD in patients with superficial drusen (r = 0.9, p = 0.03). Conclusion Impaired VD was observed in the peripapillary nasal CC in patients with ODD; this impairment was associated with a decreased RNFL thickness. Nasal SCP VD and RNFL thickness were moderately correlated in patients with ODD.
Key Messages: Optic disc drusen (ODD) are a cellular deposits discovered incidentally during routine eye exams. In some cases, ODD are associated with ocular complications related tovascular compression at the optic nerve head. Studies about vascular changes in children with ODD are very limited. This imaging study revealed initial changes in vascular density (VD), especially in choriocapillaris, in children with ODD. Optical coherence tomography angiography seems to be a promising non-invasive tool to detect early changes in patients with ODD, but prospective studies should be conducted to confirm it. Keywords Optic disk drusen . Peripapillary vessel density . Optical coherence tomography angiography . Retinal nerve fiber layer This manuscript has not been published nor submitted simultaneously for publication elsewhere. * María Alarcón-Tomas [email protected] 1
Department of Ophthalmology, University Hospital Puerta de Hierro Majadahonda, Joaquin Rodrigo 1, 28222 Madrid, Spain
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Cent
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