Mild chronic kidney disease and its relation to functional disability in Korean elderly population
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NEPHROLOGY - ORIGINAL PAPER
Mild chronic kidney disease and its relation to functional disability in Korean elderly population Sung Keun Park1 · Won Joong Kim2 · Sang Yoon Lee3 · Jae‑Hong Ryoo4 · Kangbaek Lee5 · Dong‑Young Lee6 Received: 27 March 2020 / Accepted: 29 June 2020 © Springer Nature B.V. 2020
Abstract Purpose Studies have demonstrated that chronic kidney disease (CKD) is significantly associated with the increased risk of functional difficulty in daily activity and mobility. However, data are less available for association between CKD and functional disability in Asians. Methods Using a data from Korea National Health and Nutrition Examination Survey III, we investigated the association of CKD with functional disability in 882 subjects over the age of 65. Disability was identified in activity of daily living (ADL), instrumental ADL (IADL), and visual, hearing, and walking function. The prevalence of disability was evaluated according to the stage of CKD, and multivariate logistic regression analysis was used to calculate the adjusted odds ratios (ORs) and 95% confidence interval (CI) [adjusted ORs (95% CI)] of CKD stage 3a for disability in ADL, IADL, visual, hearing, and walking function. Results Individuals with CKD stage 3–4 had the higher prevalence of disability ADL, IADL, visual, hearing, and walking function than individuals without CKD. CKD stage 3a was significantly associated with abnormal ADL [1.63 (1.04–2.54)] and visual impairment [1.39 (1.01–1.93)] even after adjusting for DM, hypertension, education, income, marital status, age, and sex. Conclusion The presence of mild CKD was significantly associated with disability in daily activity and multiple function. Keywords CKD · Elderly · Disability · ADL · IADL
Introduction
* Dong‑Young Lee [email protected] 1
Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
2
Department of Internal Medicine, Hansol Hospital, Seoul, Republic of Korea
3
Department of Environmental Medicine, Inha University Hospital, Incheon, Republic of Korea
4
Departments of Occupational and Environmental Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
5
Yonsei Miso Dental Clinic, Seongnam, Republic of Korea
6
Department of Internal Medicine, Veterans Healthcare Service Medical Center, 53, Jinhwangdo‑ro 61‑gil, Gangdong‑gu, Seoul, Republic of Korea
Function to perform routine daily task is important in maintaining quality of life. In general, this ability declines with aging [1], and the proportion of individuals suffering disability in daily task has increased by the expansion of human life span by economic growth and medical development [2, 3]. Moreover, comorbid chronic disease accelerates the decline of ability and contributes to growing prevalence of disability [4, 5]. Individuals with disability in performing task of daily life have the lower quality of life and tend to have the higher rate of hospitalization and a
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