MiR-1231 decrease the risk of cancer-related mortality in patients combined with non-small cell lung cancer and diabetes
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Cancer Cell International Open Access
PRIMARY RESEARCH
MiR‑1231 decrease the risk of cancer‑related mortality in patients combined with non‑small cell lung cancer and diabetes mellitus Jing Li2†, Jialiang Xu3†, Zhijun Cao4†, Shouzuo Du1* and Luyu Zhang1*
Abstract Background: Non-small cell lung cancer (NSCLC) is a deadly human malignancy, and previous studies support the contribution of microRNAs (miRNAs) to cancer assessment. It has been reported that miR-1231 can be used as a biomarker to assess prognosis in different cancers. However, the prognostic value of miR-1231 in NSCLC patients with comorbid diabetes mellitus (DM) remains unclear. The present study evaluated the risk factors for NSCLC with DM and developed a predictive model for it. Methods: A real-world study was conducted, including data from 108 patients with NSCLC combined with DM from April 1, 2010, to June 1, 2015. MiR-1231 was recorded during hospital admission. Cox-proportional hazards model was applied for survival analysis of risk factors for cancer-related mortality and to create nomograms for prediction. The accuracy of the model was evaluated by C-index and calibration curves. Results: The mortality rate in the high miR-1231 level (≥ 1.775) group was 57.4%. On the basis of univariate analysis, we put factors (P
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