Modifiable Factors Associated with Non-adherence to Antihypertensive or Antihyperlipidemic Drugs Are Dissimilar: a Multi
- PDF / 350,778 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 22 Downloads / 178 Views
Unit of PharmacoTherapy, -Epidemiology, & -Economics, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, the Netherlands; 2Faculty of Pharmacy, Department of Pharmacology and Clinical Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia; 3Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Jatinangor, Indonesia; 4Faculty of Pharmacy, Unit of Clinical Pharmacy and Community, Universitas Mulawarman, Samarinda, Indonesia; 5Faculty of Pharmacy, Sekolah Tinggi Ilmu Farmasi Makassar, Makassar, Indonesia; 6Faculty of Pharmacy, Department of Clinical Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia; 7 Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
BACKGROUND: To develop targeted and tailored interventions for addressing medication non-adherence, it is important to identify underlying factors. OBJECTIVE: To identify factors associated with nonadherence as well as subtypes of non-adherence to antihypertensive or antihyperlipidemic drugs among patients with type 2 diabetes in Indonesia. DESIGN: An observational multicenter cross-sectional survey. PARTICIPANTS: Patients with type 2 diabetes using either antihypertensive or antihyperlipidemic drugs in four regions in Indonesia. MAIN MEASURES: Non-adherence and its subtypes of intentional and unintentional non-adherence were assessed using the Medication Adherence Report Scale. Necessity and concern beliefs were assessed with the Beliefs about Medicines Questionnaire. We applied binary and multinomial logistic regression to assess associations of medication beliefs, sociodemographic factors, and clinical-related factors to non-adherence and report odds ratios (OR) with 95% confidence intervals (CI). KEY RESULTS: Of 571 participating patients (response rate 97%), 45.5% and 52.7% were non-adherent to antihypertensive and antihyperlipidemic drugs, respectively. Older age was associated with non-adherence to antihypertensive drugs (60–69 years) (OR, 5.65; 95% CI, 2.68– 11.92), while higher necessity beliefs (OR, 0.92; 95% CI, 0.88–0.95) were associated with less non-adherence. Factors associated with non-adherence to antihyperlipidemic drugs were female gender (OR, 1.84; 95% CI, 1.03–3.27) and higher concern beliefs (OR, 1.10; 95% CI, 1.03–1.18), while higher necessity beliefs (OR, 0.89; 95% CI, 0.83– 0.96) were associated with less non-adherence.
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11606-020-05809-y) contains supplementary material, which is available to authorized users. Received December 16, 2019 Revised February 15, 2020 Accepted March 16, 2020
CONCLUSIONS: The main factors associated with nonadherence to antihypertensive and antihyperlipidemic drugs are modifiable. In general, beliefs about the necessity of the drug are important but for antihyperlipidemic drugs concerns are important as well. Healthcare providers should pay attention to
Data Loading...
