Molecular Imaging of Depressive Disorders
This chapter summarizes findings of a large number of molecular imaging studies in the field of unipolar and bipolar depression (BD).
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Molecular Imaging of Depressive Disorders Henricus G. Ruhé, Anniek K.D. Visser, Vibe G. Frokjaer, Bartholomeus (Benno) C.M. Haarman, Hans C. Klein, and Jan Booij
Contents 5.1 5.2 5.3
Introduction .................................................................................................................... Metabolism and Cerebral Blood Flow ........................................................................... Imaging of Monoamine Systems ................................................................................... 5.3.1 Serotonin ............................................................................................................ 5.3.2 Dopamine ........................................................................................................... 5.3.3 Monoamine Oxidase Imaging ............................................................................ 5.3.4 Monoamine Depletion Imaging ......................................................................... 5.4 New Perspectives ........................................................................................................... 5.4.1 Radioligand Development for Imaging Serotonergic Neurotransmission ......... 5.4.2 Imaging of Other Neurotransmitter Systems ..................................................... 5.4.3 Imaging Inflammation and Depression .............................................................. 5.4.4 Imaging the Blood–Brain Barrier....................................................................... 5.4.5 Multimodal (Molecular) Imaging....................................................................... 5.5 Discussion and Conclusions .......................................................................................... References ...............................................................................................................................
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H.G. Ruhé, MD, PhD (*) Department of Psychiatry, Mood and Anxiety Disorders, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Department of Psychiatry, Program for Mood Disorders, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands University of Groningen, University Medical Center Groningen, University Center for Psychiatry, Hanzeplein 1, Groningen 9713 GZ, The Netherlands Mood and Anxiety Disorders, University Center for Psychiatry, University Medical Center Groningen, University of Groningen, Room 5.16., Hanzeplein 1, Groningen 9700 RB, The Netherlands e-mail: [email protected] A.K.D. Visser Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands R.A.J.O. Dierckx et al. (eds.), PET and SPECT in Psychiatry, DOI 10.1007/978-3-642-40384-2_5, © Springer-Verlag Berlin Heidelberg 2014
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V.G. Frokjaer Center for Integrated Molecular Brain Imaging and Neurobiology Research Unit, Copenhagen University Hos
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