Molecular Mechanisms of Phagocytosis
Although, Phagocytosis was first described nearly 120 year ago, we are just recently beginning to understand the molecules that phagocytic cells use to bring about this complex cell function. Molecular Mechanisms of Phagocytosis was prepared as a ser
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Molecular Mechanisms of Phagocytosis Carlos Rosales, Ph.D. Universidad Nacional Autonoma de Mexico Mexico City, Mexico
L A N D E S B I O S C I E N C E / EUREKAH.COM
GEORGETOWN, TEXAS
U.S.A.
SPRINGER SCIENCE+BUSINESS MEDIA NEW YORK, NEW YORK
U.SA
MOLECULAR MECHANISMS OF PHAGOCYTOSIS Medical Intelligence Unit Landes Bioscience / Eurekah.com Springer Science+Business Media, Inc. ISBN: 0-387-25419-6
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Library of Congress Cataloging-in-Publication Data Molecular mechanisms of phagocytosis / [edited by] Carlos Rosales. p . ; cm. ~ (Medical intelligence unit) Includes bibliographical references and index. ISBN 0-387-25419-6 1. Phagocytosis. I. Rosales, Carlos. II. Title. III. Series: Medical intelligence unit (Unnumbered : 2003) [DNLM: 1. Phagocytosis-physiology. 2. Molecular Biology. Q W 690 M718 2005] QR187.P4M64 2005 616.07'99~dc22
2005005139
For Roberto and Arturo
CONTENTS Preface 1. Diversity in Phagocytic Signaling: A Story of Greed, Sharing, and Exploitation Erick Garcia-Garcia Phagocytic Receptors (Greed) Phagocytic Signaling (Sharing) Cytoskeleton Dynamics (Exploitation) 2. Phagocytosis and Immunity Steven Greenherg Diversity of Phagocytic Receptors Mechanisms of Phagocytic Signaling Fate of Engulfed Pathogens—Us vs. Them Phagocytosis and the M H C Class II Pathway Phagocytos
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