Monoclonal antibodies
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Impaired humoral immunity: 5 case reports In a case series of 13 patients, 5 patients (3 men, 2 women) aged 20–55 years were described, who developed impaired humoral immunity during treatment with rituximab, ofatumumab or ocrelizumab for neuromyelitis optica-spectrum disorders (NMO-SD) or multiple sclerosis (MS). The patients, who were diagnosed with NMO-SD (n=1), relapsing remitting multiple sclerosis (RRMS; n=1), secondary progressive multiple sclerosis (SPMS; n=1) or primary progressive multiple sclerosis (PPMS; n=2), started receiving rituximab (n=3), ofatumumab (n=1) or ocrelizumab (n=1) [dosages and routes not stated]. All the patients concurrently had COVID-19 infection. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serology or antibody testing (IgG index) performed after >3 weeks was found to be negative in all patients, which was suggestive of impaired humoral response, which was attributed to the immunosuppressive therapies [durations of treatments to reactions onsets and outcomes not stated]. Maillart E, et al. Beyond COVID-19: DO MS/NMO-SD patients treated with anti-CD20 therapies develop SARS-CoV2 antibodies?. Multiple Sclerosis and Related Disorders 803505010 46: Nov 2020. Available from: URL: http://doi.org/10.1016/j.msard.2020.102482
0114-9954/20/1824-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
Reactions 3 Oct 2020 No. 1824
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