Morphology and transport in biodegradable polymer compositions based on poly(3-hydroxybutyrate) and polyamide 54C
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Morphology and Transport in Biodegradable Polymer Compositions Based on Poly(3-Hydroxybutyrate) and Polyamide 54C A. L. Zhul’kina, E. L. Ivantsova, A. G. Filatova, R. Yu. Kosenko, K. Z. Gumargalieva, and A. L. Iordanskii Semenov Institute of Chemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 119991 Russia e-mail: [email protected] Received October 9, 2008
Abstract—Complex investigation of the equilibrium sorption of water, diffusive transport of antiseptic, and morphology of mixed compositions based on polyoxybutirate and polyamide resin 54C has been performed to develop and analyze new biodegradable polymer compositions for controlled release of medicinal substances. Samples of mixtures were prepared by two methods: pressing under pressure and solvent evaporation from a polymer solution. The samples were compared and their morphology was analyzed by scanning electron microscopy. It is shown that the component ratio in the obtained mixtures affects their morphological, transport, and sorption characteristics. PACS numbers: 87.85.Jf, 87.85.Tu DOI: 10.1134/S1063774509030158
INTRODUCTION This study is devoted to the fabrication and analysis of new biodegradable polymers compatible with the surrounding natural medium or tissues of an organism [1]. The goal is to develop methods for obtaining a mixed poly-3-hydroxybutyrate/polyamide composition (PHB/PA-54C) with different component ratios and controlling its morphology and water transport as the main factor responsible for the hydrolytic destruction rate. Bacterial PHB [2, 3] belongs to the class of biodegradable highly crystalline polymers whose natural sources (sugars) are reproducible. This biopolymer is thermoplastic and, therefore, can easily be processed by extrusion, molding, pressing, etc. In addition, PHBbased materials have enhanced brittleness [4] and their preparation is hindered by a high melting temperature (180°ë), which is close to the decomposition temperature (190°ë).
Differences in the morphological characteristics of films of variable composition (PHB/PA-54C) and different history make it possible to control the diffusion and sorption capacity of water and the release rate of antiseptic (5-nitrofurfurylidene semicarbazone) to develop a new generation of therapeutic systems for address delivery of medicine [6]. The morphological specific features of mixed PHB/PA-54C compositions grown from a melt or solution were revealed by scanning electron microscopy. OBJECTS OF STUDY We used poly-3-hydroxybutyrate in the form of finegrained powder from the manufacturer (0997 grade, Biomer, Germany). The structural formula is H–[–O– CH(CH3)CH2COO–]n–OH: O H
CH3
.
O n
To improve the mechanical characteristics of PHB, it is modified in two different ways: by introducing comonomers (oxyvalerates, oxide octanoates, etc.) into the biomacromolecule via copolymerization or by mixing with other synthetic polymers [5] in solutions or melts. The latter process has certain advantages because in this case preparation o
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