MR imaging of epithelial ovarian cancer: a combined model to predict histologic subtypes
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MR imaging of epithelial ovarian cancer: a combined model to predict histologic subtypes LuoDan Qian 1 & JiaLiang Ren 2 & AiShi Liu 1 & Yang Gao 1 & FenE Hao 1 & Lei Zhao 1 & Hui Wu 1 & GuangMing Niu 1 Received: 23 September 2019 / Revised: 15 April 2020 / Accepted: 28 May 2020 # European Society of Radiology 2020
Abstract Objective To compare the performance of clinical features, conventional MR image features, ADC value, T2WI, DWI, DCEMRI radiomics, and a combined multiple features model in predicting the type of epithelial ovarian cancer (EOC). Methods In this retrospective analysis, 61 EOC patients were confirmed by histology. Significant features (p < 0.05) by multivariate logistic regression were retained to establish a clinical model, conventional MRI morphological model, ADC model, and traditional model. The radiomics model included FS-T2WI, DWI, and DCE-MRI, and also, a multisequence model was established. A total of 1070 radiomics features of each sequence were extracted; then, univariate analysis and LASSO were used to select important features. Traditional models were combined with a combined radiomics model to establish a mixed model. The predictive performance was validated by receiver operating characteristic curve (ROC) analysis, calibration curve, and decision curve analysis (DCA). A stratified analysis was conducted to compare the differences between the combined radiomics model and the traditional model in identifying early- and late-stage EOC. Results Traditional models showed the highest performance (AUC = 0.96). The performance of the mixed model (AUC = 0.97) was not significantly different from that of the traditional model. The calibration curve showed that the traditional model had the highest reliability. Stratified analysis showed the potential of the combined radiomics model in the early distinction of the two tumor types. Conclusion The traditional model is an effective tool to distinguish EOC type I/II. Combined radiomics models have the potential to better distinguish EOC types in early FIGO stage disease. Key Points • The combined radiomics model resulted in a better predictive model than that from a single sequence model. • The traditional model showed higher classification accuracy than the combined radiomics model. • Combined radiomics models have the potential to better distinguish EOC types in early FIGO stage disease. Keywords Epithelial ovarian cancer . Histopathology . Radiomics . Magnetic resonance imaging
LuoDan Qian and JiaLiang Ren contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00330-020-06993-5) contains supplementary material, which is available to authorized users. * Hui Wu [email protected] * GuangMing Niu [email protected] 1
Department of Radiology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010000, China
2
GE Healthcare (Shanghai) Co., Ltd., Shanghai 210000, China
Abbreviations ADC Apparent diffusion coefficient DCA Decision
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