Multi-institutional development and validation of a nomogram to predict recurrence after curative resection of gastric n
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ORIGINAL ARTICLE
Multi‑institutional development and validation of a nomogram to predict recurrence after curative resection of gastric neuroendocrine/mixed adenoneuroendocrine carcinoma Hualong Zheng1,2 · YaJun Zhao3 · Qingliang He4 · Hankun Hao5 · Yantao Tian6 · Bingbing Zou7 · Lixin Jiang8 · Xiantu Qiu9 · Yanbing Zhou10 · Zhi Li11 · Yanchang Xu12 · Gang Zhao13 · Fangqin Xue14 · Shuliang Li15 · Weihua Fu16 · Yongxiang Li7 · Xiaojun Zhou17 · Yong Li18 · Zhenggang Zhu19 · Jinping Chen20 · Zekuan Xu21 · Lisheng Cai22 · En Li23 · Honglang Li24 · Jianwei Xie1,2 · Chaohui Zheng1,2 · Jun Lu1,2 · Ping Li1,2 · Changming Huang1,2 Received: 6 May 2020 / Accepted: 4 August 2020 © The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2020
Abstract Objective To establish a novel nomogram to predict individual 1, 3, and 5 years disease-free survival (DFS) of patients with gastric neuroendocrine carcinoma/mixed adenoneuroendocrine carcinoma [(MA)NEC]. Background Among patients undergoing radical resection of gastric (MA)NEC, there is still a high tendency for relapse. Methods A retrospective analysis of 777 patients with gastric (MA)NEC at 23 centers in China from 2004 to 2015 was performed. Based on the established nomogram, which included age, ASA, pT, pN and Ki67, the overall patients were divided into low-risk group (LRG) and high-risk group (HRG). Results The median follow-up time was 40 months (1–169 months). The C-index, AUC and time-ROC of the nomogram were significantly higher than that of the 8th edition AJCC and ENETS TNM staging systems. The 3-year DFS of patients in HRG generated by the nomogram was significantly lower than that in LRG (all patients: 35% vs 66.9%, p
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