Multi-System Endocrine Disruption
Endocrine disruption is an expanding field due to the numerous chemicals involved and, as evidenced more recently, the variety of homeostatic systems that they can alter throughout life. The gathering of experts from all over the world should help to iden
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Jean-Pierre Bourguignon Bernard Je´gou Bernard Kerdelhue´ Jorma Toppari Yves Christen l
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Editors
Multi-System Endocrine Disruption
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Editors Prof. Dr. Jean-Pierre Bourguignon University of Lie`ge Developmental Neuroendocrinology Unit, G Place du XX Aout 7 4000 Lie`ge Belgium [email protected] PD Dr. Bernard Kerdelhue´ Centre Universitaire des SaintsPe`res Inserm U648, UFR Biome´dicale 75006 Paris Cedex 06 France bernard.kerdelhue@biomedicale. univ-paris5.fr
Prof. Dr. Bernard Je´gou GERHM Inserm U625 Campus de Beaulieu Avenue du Ge´ne´ral Leclerc 35042 Rennes France [email protected] Prof. Dr. Jorma Toppari University of Turku Departments of Physiology and Paediatrics Kiinamyllynkatu 10 20520 Turku Finland [email protected]
Dr. Yves Christen Fondation IPSEN pour la Recherche Therapeutique 65 quai George Gorse 92650 Boulogne Billancourt Cedex France [email protected]
ISSN 1861-2253 ISBN 978-3-642-22774-5 e-ISBN 978-3-642-22775-2 DOI 10.1007/978-3-642-22775-2 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2011936750 # Springer-Verlag Berlin Heidelberg 2011 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
In the field of endocrine disruption, the reproductive system has been a priority concern of scientists and environment/public health agencies for several decades, based on observations of fertility impairment in wildlife as well as in humans. In women, intrauterine exposure to diethylstilbestrol (DES) raised the issue of carcinogenicity as early as the 1970s. Although this synthetic compound has been banned for many years, there are still unclear matters of concern such as transgenerational epigenetic effects that provide rationale for monitoring the third generation descending from exposed pregnant women. Another lesson drawn from decades of research is the widened scope of the endpoints of repro-endocrine disruption. In the male, beyond germ cell line differentiation and semen quality, other targets involve testicular descent, epididymis, prostate and external genitalia. The list of p
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