Multifocal electroretinography in type 2 idiopathic macular telangiectasia
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Multifocal electroretinography in type 2 idiopathic macular telangiectasia Raja Narayanan & Vivek Dave & Padmaja K. Rani & Jay Chhablani & Harsha B. Rao & Rajeev R. Pappuru & Subhadra Jalali
Received: 8 May 2012 / Revised: 18 October 2012 / Accepted: 22 October 2012 / Published online: 6 November 2012 # Springer-Verlag Berlin Heidelberg 2012
Abstract Background To characterize the electroretinographic response of the macula by multifocal electroretinography (mfERG) in patients with type 2 idiopathic macular telangiectasia (MacTel). Methods A prospective study of mfERG in patients with type 2 MacTel was conducted from April 2009 to November 2009. mfERGs were recorded using a visual evoked response imaging system (MonElec2, Metrovision, Perenchies, France). The International Society for Clinical Electrophysiology of Vision (ISCEV) guidelines were followed. Patients with type 2 MacTel confirmed by fundus fluorescein angiography without subretinal neovascularisation were included. For recording purposes, 61 stimulus hexagonal elements were used. The first-order kernel Presented at the International Society for Clinical Electrophysiology of Vision meeting, Fremantle, Western Australia, November 2010, and the American Society of Retina Specialists meeting, Vancouver, Canada, September 2010 Authors have full control of all primary data, and we agree to allow Graefe’s Archive for Clinical and Experimental Ophthalmology to review their data upon request. R. Narayanan : V. Dave : P. K. Rani : J. Chhablani : R. R. Pappuru : S. Jalali Smt. Kanuri Santhamma Vitreo-Retina Center, Hyderabad Eye Research Foundation, LV Prasad Eye Institute, Hyderabad, India H. B. Rao Center for Clinical Epidemiology and Biostatistics, L V Prasad Eye Institute, Hyderabad, India R. Narayanan (*) LV Prasad Eye Institute, LV Prasad Marg, Banjara Hills, Hyderabad 500034, India e-mail: [email protected]
mfERG responses were analyzed. Individual mfERG responses for the hexagons were grouped into concentric rings centered on the fovea for analysis (< 2, 5–10, 10–15 and >15°). Student’s t-test and Mann–Whitney U test and linear regression analysis was performed with STATA ver 11.1 (StataCorp, College Station , TX, USA). Results Twenty eight eyes of 14 patients and 20 eyes of ten normal controls were included in the study. The mean logMAR visual acuity of the patients was 0.51 (Snellen equivalent 20/63). The mean N1 amplitude (nv/deg2) of patients were significantly reduced compared to controls and were as follows: 8.91±14.00 vs 43.44±9.55 (p
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