Multiple Primary Malignancies
Two to three decades ago, multiple primary malignancies (MPM) were considered to be simply a clinical curiosity, with sporadic reports, mostly single case descriptions, found in the literature. While in the last few years, analyses of larger series have b
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Andrea Renda
Multiple Primary Malignancies
In cooperation with Luigi Marchiori Silvia Pachera Luca Bortolasi Riccardo Manfredi Paola Capelli
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Andrea Renda Surgical, Anesthesiology-rianimative and Emergency Sciences Department Federico II University Naples, Italy
The publication and the distribution of this volume have been supported by the Italian Society of Surgery The Editor acknowledges the educational contribution offered by Johnson & Johnson Medical S.p.A.
Library of Congress Control Number: 2008936505 ISBN 978-88-470-1094-9 Springer Milan Berlin Heidelberg New York e-ISBN 978-88-470-1095-6 Springer is a part of Springer Science+Business Media springer.com © Springer-Verlag Italia 2009 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is only permitted under the provisions of the Italian Copyright Law in its current version, and permission for use must always be obtained from Springer. Violations are liable for prosecution under the Italian Copyright Law. The use of general descriptive names, registered names, trademarks, etc., in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover design: Simona Colombo, Milan, Italy Typesetting: Graphostudio, Milan, Italy Printing and binding: Arti Grafiche Nidasio, Assago, Italy Printed in Italy Springer-Verlag Italia S.r.l. – Via Decembrio 28 – I-20137 Milan
In loving memory of Gaetano Renda, Giuseppe Zannini and Simone Renda
Foreword
In 2006, when my colleague Andrea Renda proposed multiple primary malignancies (MPM) as the subject of the Biennial Report to the 2008 Congress of the Italian Society of Surgery, I, together with the Steering Committee, quickly agreed. Recent progress in our understanding of the etiopathology of these neoplasms has led to innovative and significant progress on the clinical level. Importantly, the incidence of the onset of two or more tumors in the same patient suggests a more than casual relationship. Furthermore, the occurrence of MPM derives from several different mechanisms—viral, iatrogenic, immunologic, environmental, and hereditary—such that any form of treatment must take into account the etiology of these tumors. After an epidemiological introduction, this monograph analyzes various aspects of multitumoral syndromes based on the experience of the Department of Surgical Sciences, along with that of other clinical departments of the University Federico II of Naple
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