Myeloma Therapy Pursuing the Plasma Cell
Therapeutic options for patients with myeloma have radically changed over the past ten years. Myeloma Therapy: Pursuing the Plasma Cell provides updated various treatment options for patients with myeloma, with focus on the emerging and speculative aspect
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CONTEMPORARY
H E M ATO L O G Y
Judith E. Karp, Series Editor
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Myeloma Therapy Pursuing the Plasma Cell First Edition
Edited by
Sagar Lonial, MD Winship Cancer Institute Atlanta, GA
Editor Sagar Lonial Emory University Winship Cancer Institute B3307 Clifton Road Atlanta, GA 30322 USA [email protected] Series Editor Judith E. Karp The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Division of Hematologic Malignancies Baltimore, Maryland 21231
ISBN: 978-1-934115-82-4 e-ISBN: 978-1-59745-564-0 DOI: 10.1007/978-1-59745-564-0 Library of Congress Control Number: 2008933590 © 2008 Humana Press, a part of Springer Science+Business Media, LLC All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, 999 Riverview Drive, Suite 208, Totowa, NJ 07512 USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper 9 8 7 6 5 4 3 2 1 springer.com
Dedication
To my Parents and Teachers who provided the tools, To the Patients who provided the motivation, To Jennifer, Hallie, and Ben who provided the inspiration. This book would not have been possible without you. Sagar Lonial
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Preface
Therapeutic options for patients with myeloma have dramatically changed over the past 10 years. Beginning with the advances in therapy resulting from the use of high-dose therapy and autologous bone marrow or stem cell transplant, we have more than doubled the median survival for patients as a whole, and have now have a wealth of different biology -based treatment approaches for our patients in all disease stages. This book represents state-of-the-art information from many of the leaders in the plasma cell disorders world. Sections focusing on disease pathogenesis and biology, chemotherapy-based approaches, immune -based therapies, currently approved novel agents, developing targets, supportive care, and other plasma cell disorders provides a comprehensive collection and an excellent resource in this time of rapid change in clinical and preclinical disease knowledge. It is important to realize that
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