Nanoscale Surface Modification for Enhanced Biosensing A Journey Tow
This book gives a comprehensive overview of electrochemical-based biosensors and their crucial components. Practical examples are given throughout the text to illustrate how the performance of electrochemical-based biosensors can be improved by nanoscale
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Nanoscale Surface Modification for Enhanced Biosensing A Journey Toward Better Glucose Monitoring
Nanoscale Surface Modification for Enhanced Biosensing
Guigen Zhang
Nanoscale Surface Modification for Enhanced Biosensing A Journey Toward Better Glucose Monitoring
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Guigen Zhang Department of Bioengineering Clemson University Clemson, SC, USA
ISBN 978-3-319-17478-5 ISBN 978-3-319-17479-2 (eBook) DOI 10.1007/978-3-319-17479-2 Library of Congress Control Number: 2015938696 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www. springer.com)
I would like to dedicate this book to my family, my wife Sucheng and sons Andrew and Gordon, for their unconditional support over the years.
Preface
By surface modification, we often refer to modification of the surface of an implant so that better integration of the implant with surrounding tissues can be achieved. It has rarely been put in the same context as biosensors. In our journey to develop biosensors with enhanced performance by taking advantage of nanotechnology, we learned that surface modification actually plays some crucial roles in affecting the performance of these biosensors. This book provides a whole-spectrum view of the interdependence between surface modification (both physically and chemically) and key parts of a biosensor, including electrode surface area, electrode functionalization, enzyme stability, and mass transport. In Chap. 1, biosensors are defined and their basic requirements are discussed with respect to other types of sensors. A brief overview of the two major components of biosensors—sensitive elements and signal transduction techniques—is given. For the sensitive elements, the most commonly used ones including antibodies, nucleotides, enzymes, cells, and synthetic molecules
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