Nanotexturization of Ti-based implants in simulated body fluid: Influence of synthesis parameters on coating properties
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Nanotexturization of Ti-based implants in simulated body fluid: Influence of synthesis parameters on coating properties and kinetics of drug release Carlise Hannel Ferreira1 , Anna Paulla Simon1, Vidiany Aparecida Queiroz Santos1, Andressa Rodrigues2, Janaina Soares Santos2, Francisco Trivinho-Strixino2, Patrícia Teixeira Marques1, Mariana de Souza Sikora1,a) 1
Department of Chemistry, Federal Technological University of Paraná (UTFPR), Pato Branco, PR 85503-390, Brazil Department of Physics, Chemistry and Mathematics, UFSCar, Sorocaba, SP 18052-780, Brazil a) Address all correspondence to this author. e-mail: [email protected] 2
Received: 13 February 2019; accepted: 4 June 2019
In the present study, TiO2NT coatings grown on simulated body fluid-based electrolyte were investigated as drug delivery devices. Nanotubes (NTs) were grown over commercially pure Ti and Ti6Al4V alloy. Morphology analysis showed that NTs in alloy samples present an inner diameter of 10 nm smaller in average than NTs grown over pure Ti. The surface wettability in water decreased with the anodizing time for both substrates. The application of coatings as drug delivery devices has been studied through the incorporation of ciprofloxacin. To control the drug release, collagen was used as the diffusional barrier. It was observed the drug release follows a Fick’s kinetics. Bioactivity assays showed the absence of hemolytic activity. The concentration of the drug during the release interval remained below the toxic concentration limit, presenting a bacteriostatic activity. All coatings prepared presented a high antibacterial activity, being the area of inhibition of bacterial growth above 13 times the area of the implant.
Introduction The application of synthetic biomaterials for the regeneration of bone tissue as an alternative to bone grafts, both in orthopedics and in orthodontics, has many advantages [1]. These include a low risk of contamination by bacteria and viruses, providing a material according to the patient needs. The most widely used biomaterials are polymers, ceramics, composites, and also metals. These materials can be used to replace some parts of the body, although its surface composition is tailored regarding the application and depending on the need and location that the device will be implanted. In this sense, metal biomaterials are commonly used in prostheses that need a greater mechanical resistance. In these classes of biomaterials, the investigations associated with titanium and its alloys are mainly motivated by some unique characteristics of this material, such as low compression, low corrosion [2], low toxicity, and modulus of elasticity closer to human bone [3].
ª Materials Research Society 2019
However, to achieve this corrosion resistance, this metal is most often coated with a thin film of titanium dioxide (TiO2) [4, 5, 6]. Finally, several studies have shown that the nanotexturization of titanium and its alloys can increase the biocompatibility of the implant and facilitate the process of osseointegration
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