Natalizumab
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Natalizumab Type III allergic reaction: case report A 35-year-old woman, with relapsing-remitting multiple sclerosis not responding to interferon β-1b, began treatment with natalizumab [dosage not stated]. Ten days after receiving her second infusion she developed whole-body rash and itching. Her primary care physician suspected an allergic reaction and treated her with dimetindene for 5 days. However natalizumab was not suspected and infusions continued. She received a third and fourth infusion with symptoms recurring 10 days later; the rash and itching were treated as before. After the third occurrence she reported her symptoms to those administering her natalizumab. Natalizumab was discontinued and her serum analysed, revealing anti-natalizumab antibodies [outcome not stated]. Leussink VI, et al. Type III systemic allergic reaction to natalizumab. Archives of 801111640 Neurology 65: 851-852, No. 6, Jun 2008 - Germany
0114-9954/10/1207-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 21 Jun 2008 No. 1207
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