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Cris S. Constantinescu Razvan I. Arsenescu Violeta Arsenescu Editors

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Neuro-Immuno-Gastroenterology

Cris S. Constantinescu Razvan I. Arsenescu • Violeta Arsenescu Editors

Neuro-ImmunoGastroenterology

Editors Cris S. Constantinescu University Hospital University of Nottingham Nottingham United Kingdom

Violeta Arsenescu Armedica LLC Basking Ridge, OH USA

Razvan I. Arsenescu Atlantic Digestive Health Institute Morristown Medical Center Morristown, OH USA

ISBN 978-3-319-28607-5 ISBN 978-3-319-28609-9 DOI 10.1007/978-3-319-28609-9

(eBook)

Library of Congress Control Number: 2016941539 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland

CSC would like to dedicate this book to his parents, who have inspired his interest in interdisciplinary science. RA & VA dedicate this book to their son, Victor, their beacon of light and constant source of inspiration.

Preface

The multidirectional interaction between the immune system, the gut and the brain has only become subject of more intense research interest in the last few years. Much work has been done in neuroimmunology and in the immunology and immunopathogenesis of the gastrointestinal tract, and the influence of the nervous system on both immune functions (neuroimmunomodulation and nerve-driven immunity) and on gastrointestinal processes has been studied in detail. However, to date, no dedicated forum exists, either in the form of a scientific journal or in the form of a book, which addresses issues at the interface between the three biological disciplines, and in which the dialogue on specific common issues between neuroimmunologists and immuno-gastroenterologists can take place. Recent discoveries in fundamental immunology require an intensification of this dialogue, so that understanding by scientists of one d