Neurobiology of Actin From Neurulation to Synaptic Function
Neurons are characterized by a complex, dynamic and highly polarized morphology. Actin and its regulatory proteins are the most abundant set of proteins within cells, and they form one of the major cytoskeletal systems—the actin filament cytoskeleton. Whi
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Series Editor Arne Schousboe
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Gianluca Gallo · Lorene M. Lanier Editors
Neurobiology of Actin From Neurulation to Synaptic Function
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Editors Gianluca Gallo Department of Neurobiology and Anatomy Drexel University College of Medicine 2900 Queen Lane Philadelphia, PA 19129, USA [email protected]
Lorene M. Lanier Department of Neuroscience University of Minnesota 321 Church St. Minneapolis, MN 55455, USA [email protected]
ISSN 2190-5215 e-ISSN 2190-5223 ISBN 978-1-4419-7367-2 e-ISBN 978-1-4419-7368-9 DOI 10.1007/978-1-4419-7368-9 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010938621 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
1 Introduction to the Neurobiology of Actin . . . . . . . . . . . . . . Gianluca Gallo
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2 The Neuronal Actin Cytoskeleton and the Protrusion of Lamellipodia and Filopodia . . . . . . . . . . . . . . . . . . . . . . Gianluca Gallo
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3 Regulation of Actin Filaments During Neurite Extension and Guidance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Paul Letourneau
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4 Functions of Myosin Motor Proteins in the Nervous System . . . . Daniel M. Suter
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5 Microtubule–Actin Interactions During Neuronal Development . . Kenneth A. Myers and Peter W. Baas
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6 Working with Actin: Methodological Approaches for the Study of Actin in Neurons . . . . . . . . . . . . . . . . . . . . . . . Erik W. Dent
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7 Functions of the Actin Cytoskeleton in the Early Embryology of the Nervous System . . . . . . . . . . . . . . . . . . Jeffrey D. Hildebrand
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8 Actin Cytoskeletal Regulation in Neuronal Migration . . . . . . . . M. Elizabeth Ross and Stanislav Kholmanskikh
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9 Actin and Neuronal Polarity . . . . . . . . . . . . . . . . . . . . . . Annette Gärtner and Carlos G. Dotti
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Actin at the Synapse: Contribution to Pre- and Postsynaptic Functions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Dezhi Liao Actin and Diseases of the Nervous System . . . . . . . . . . . . . . Barbara W. Bernstein, Michael T. Maloney, and James R. Bamburg
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Contents
Signal Transduction Pathways: From Receptor to the Actin Cytos
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