Neuroendocrinology of Male Reproductive Behavior
Berthold, working in the mid-nineteenth century, first published data linking the endocrine secretions of the rooster testes to the display of masculine courtship behavior. Since then hundreds of experiments have been published showing that testosterone i
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Neuroendocrinology of Male Reproductive Behavior
M. J. Baum
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Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2
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Methods of Studying Appetitive versus Consummatory Components of Male Sexual Behavior as well as Erectile Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
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Activation of Male‐typical Sexual Behavior and Penile Erection by Testosterone and its Neural Metabolites, Estradiol and Dihydrotestosterone . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Effects of Castration and Systemic Administration of Steroids or Antagonist Drugs . . . . . . . . . . . . . . 5 Species and Genotype Variations in the Effects of Castration and Hormone Replacement on Male Sexual Behavior . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Effects of Hypothalamic Implantation of T, E, DHT or Antagonist Drugs on the Expression of Sexual Behavior . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Extra‐Hypothalamic Sites of Sex‐Steroid Activation of Male Sexual Behavior . . . . . . . . . . . . . . . . . . . . 11 MPOA/AH Sex Steroid–Dopamine Relationships in the Control of Male Sexual Behavior . . . . . . 13 Androgenic Facilitation of Penile Erectile Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14
3.1 3.2 3.3 3.4 3.5 3.6 4 4.1 4.2 4.3 4.4
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Sex Steroids, Acting Perinatally in the Male Brain, ‘‘Organize’’ Neural Mechanisms Controlling Male‐Typical Mating Behavior . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Contribution of Testosterone (T) Acting via Androgen Receptor (AR) . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 Contribution of E, Aromatized in Brain from T, Acting via E Receptor (ER) a and b . . . . . . . . . . . 17 Possible Interactions of AR and ERa in the Organization of Male Sexual Behavior . . . . . . . . . . . . . . 18 Steroid Receptor Coactivators, GABA, and Prostaglandin‐E2 as Possible Mediators of Sex Hormone‐Dependent Behavioral Masculinization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 Relationship Between Sexually Dimorphic Hypothalamic Morphology and Male‐Typical Sexual Behavior and Partner Preference . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22
Springer-Verlag Berlin Heidelberg 2007
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Neuroendocrinology of male reproductive behavior
Abstract: Berthold, working in the mid‐nineteenth century, first published data linking the endocrine secretions of the rooster testes to the dis
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