Neuroprotective Therapy for Stroke and Ischemic Disease
This book is a critical and comprehensive look at current state-of-the-art scientific and translational research being conducted internationally, in both academia and industry; it serves to address new ways to provide effective treatment to victims of isc
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Paul A. Lapchak John H. Zhang Editors
Neuroprotective Therapy for Stroke and Ischemic Disease
Springer Series in Translational Stroke Research
Series Editor John Zhang Loma Linda, USA
More information about this series at http://www.springer.com/series/10064
Paul A. Lapchak • John H. Zhang Editors
Neuroprotective Therapy for Stroke and Ischemic Disease
Editors Paul A. Lapchak Department of Neurology and Neurosurgery Cedars-Sinai Medical Center Los Angeles, CA, USA
John H. Zhang Loma Linda University School of Medicine Loma Linda, CA, USA
ISSN 2363-958X ISSN 2363-9598 (electronic) Springer Series in Translational Stroke Research ISBN 978-3-319-45344-6 ISBN 978-3-319-45345-3 (eBook) DOI 10.1007/978-3-319-45345-3 Library of Congress Control Number: 2016955837 © Springer International Publishing Switzerland 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
This is a very timely compilation of cutting-edge aspects of neuroprotective therapy for ischaemic stroke in a myriad of clinical and experimental situations. It was assembled by basic and clinical scientists at a time well after the dust had settled on the subject, following the difficulties of translating neuroprotection from bench to bedside. However, we are still mystified as to why this translational gap persists although numerous possible explanations have been given, in what now must be thousands of review articles. The book is logically and easily divided into four sections, ranging from the historical aspects of neuroprotection right through to the very latest aspects of clinical trial design. Several positives have come from the difficulties experienced in translation of neuroprotective therapies, and these are all brought out nicely in this volume. First, there is
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