Neuroradiologic manifestations of COVID-19: what the emergency radiologist needs to know
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REVIEW ARTICLE
Neuroradiologic manifestations of COVID-19: what the emergency radiologist needs to know Michael F. Goldberg 1
&
Morton F. Goldberg 2
Received: 16 June 2020 / Accepted: 10 August 2020 # American Society of Emergency Radiology 2020
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a global pandemic with a wide spectrum of clinical signs and symptoms. Neurologic manifestations are relatively common, with severe cases often demonstrating striking findings on neuroimaging. Because the neuroradiologic findings may be the first evidence of COVID-19, the emergency radiologist has a critical role to play in not only the detection and management of the disease but also in the safety of other patients and hospital staff. Therefore, radiologists, especially those who specialize in emergency radiology, need to be aware of the neuroradiologic manifestations of COVID-19. Keywords COVID-19 . Encephalopathy . PRES . SARS-CoV-2 . Stroke
Introduction Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a global pandemic that began in December 2019 in Wuhan, China [1]. Since the initial outbreak, COVID-19 has spread rapidly across over 200 countries, resulting in over 18 million confirmed cases and over 700,000 deaths [2]. In the USA, there have been cases reported in all 50 states, resulting in over 4.7 million confirmed cases and over 150,000 deaths [2]. Although typical symptoms are mild, including fever, cough, dyspnea, diarrhea, and myalgies, severe disease often results in pneumonia and subsequent acute respiratory distress syndrome (ARDS) [3]. Pulmonary disease is the most common source of morbidity and mortality in severely affected COVID-19 patients, but there is a substantial body of literature indicating that a variety of neurologic manifestations also characterize this disease. In a study of 214 COVID-19 patients in Wuhan, China, for example, 36% had neurologic manifestations [4]. These
* Michael F. Goldberg [email protected] 1
Division of Neuroradiology, Imaging Institute, Allegheny Health Network, Pittsburgh, PA, USA
2
Department of Ophthalmology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
neurologic manifestations were more common in severely affected patients, tended to occur early in the disease course, and could be the initial, presenting clinical evidence of COVID-19 [4]. There are a variety of reported neurologic signs and symptoms of COVID-19, ranging from mild to severe. These include, most commonly, dizziness, headache, delirium, and impaired consciousness [4, 5]. Because the neuroradiologic findings may be the first evidence of COVID-19, the emergency radiologist has a critical role to play in not only the detection and management of the disease but also in the safety of other patients and hospital staff. Therefore, radiologists, especially those who specialize in emergency radiology, need to be aware of the neuroradiologic manifestations
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