New Radiotherapy Techniques for the Prevention of Radiotherapy-Induced Xerostomia

External beam radiotherapy is a commonly used treatment for the primary and post-operative treatment of head and neck cancer (HNC). The effects of ionising radiation on the parotid and submandibular glands have been investigated in preclinical studies and

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Dry Mouth A Clinical Guide on Causes, Effects and Treatments

Dry Mouth

Guy Carpenter Editor

Dry Mouth A Clinical Guide on Causes, Effects and Treatments

Editor Guy Carpenter Department of Salivary Research Kings College London Dental Institute London UK

ISBN 978-3-642-55153-6 ISBN 978-3-642-55154-3 DOI 10.1007/978-3-642-55154-3 Springer Heidelberg New York Dordrecht London

(eBook)

Library of Congress Control Number: 2014953246 © Springer-Verlag Berlin Heidelberg 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher's location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

Contents

Part I 1

Background Topics

Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Guy Carpenter

Part II

3

Causes

2

Diseases Causing Oral Dryness. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Anne Marie Lynge Pedersen

7

3

Medication-Induced Dry Mouth. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Gordon B. Proctor

33

4

Cancer-/Cancer Treatment-Related Salivary Gland Dysfunction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Andrew N. Davies

Part III

51

Effects

5

Oral Dryness, Dietary Intake, and Alterations in Taste . . . . . . . . . . . Anja Weirsøe Dynesen

69

6

Xerostomia and the Oral Microfl