New treatment method for refractory gastroesophageal reflux disease (GERD): C-BLART (clip band ligation anti-reflux ther
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and Other Interventional Techniques
New treatment method for refractory gastroesophageal reflux disease (GERD): C‑BLART (clip band ligation anti‑reflux therapy)—a short‑term study Shengzhen Liu1 · Ningli Chai1 · Yaqi Zhai1 · Jiale Zou1 · Xiuxue Feng1 · Zhenjuan Li1 · Longsong Li1 · Xiaobin Zhang1 · Xiaoxiao Wang1 · Shasha Wang1 · En‑Qiang Linghu1 Received: 11 April 2019 / Accepted: 28 October 2019 © Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract Objectives C-BLART (clip band ligation anti-reflux therapy) has been reported as a new alternative endoscopic treatment for refractory gastroesophageal reflux disease (GERD). This study evaluated the short-term efficacy of C-BLART for controlling GERD symptoms, esophageal acid exposure, esophagitis, and quality of life. Methods Patients with refractory GERD were recruited for a nonrandomized concurrent comparison, with 60 patients in the C-BLART with tailored PPI use group and 43 patients in the BID proton pump inhibitor (PPI) group. The primary outcomes were esophageal acid exposure and the lower esophageal sphincter (LES) pressure. The GERD-Q score, esophagitis grade, and adherence degree were also recorded. Crossover from the BID PPI group to the C-BLART with tailored PPI use group was allowed after 6 months. Results The LES pressure and GERD-Q score improved more in the C-BLART with tailored PPI use group (P
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