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Nitrofurantoin/penicillins Acquired drug resistance: case report

An elderly woman [age not stated] acquired resistance to nitrofurantoin and unspecified penicillins while being treated for Enterococcus faecalis urinary tract infection (UTI)* . The woman, who had type 2 diabetes mellitus, presented with low-grade fever with chills and dysuria in the last two weeks. The urine culture was positive, and the isolate was identified as Enterococcus faecalis showing resistance to various drugs. It was found to be sensitive to linezolid, vancomycin, penicillin and nitrofurantoin. She was prescribed a course of nitrofurantoin 100mg twice daily (BD) for 14 days and an unspecified penicillins [routes not stated; not all dosages stated]. However, despite treatment her symptoms failed to improve even after a week and repeat urine culture grew Enterococcus faecalis with acquired resistance to nitrofurantoin and unspecified penicillins. Additionally, she was receiving treatment with metformin and insulin degludec concomitantly. Thereafter, the woman was treated with linezolid. Defervescence was observed within 48 hours, and she became completely symptom-free with a negative urine culture at the end of three weeks. * Country of occurrence, reporter country and primary source country not stated. Author’s communication details not available. Hinduja A, et al. Multi-drug resistant community-acquired enterococcus faecalis urinary tract infection in an elderly diabetic female. International Journal of Diabetes in Developing Countries 39 (Suppl.): S18 (plus poster) abstr. PP07, No. 1, Nov 2019. Available from: URL: http://doi.org/10.1007/s13410-019-00782-7 [abstract] 803514824

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Reactions 14 Nov 2020 No. 1830