Non-invasive assessment of liver fibrosis in autoimmune hepatitis: Diagnostic value of liver magnetic resonance parametr
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SPECIAL SECTION: DIFFUSE LIVER DISEASE
Non‑invasive assessment of liver fibrosis in autoimmune hepatitis: Diagnostic value of liver magnetic resonance parametric mapping including extracellular volume fraction Narine Mesropyan1,2 · Patrick Kupczyk1,2 · Leona Dold3 · Tobias J. Weismüller3 · Alois M. Sprinkart1,2 · Burkhart Mädler4 · Claus C. Pieper1 · Daniel Kuetting1,2 · Christian P. Strassburg3 · Ulrike Attenberger1 · Julian A. Luetkens1,2 Received: 16 July 2020 / Revised: 7 October 2020 / Accepted: 10 October 2020 © The Author(s) 2020
Abstract Purpose Autoimmune hepatitis (AIH) is an immune-mediated chronic liver disease that leads to severe fibrosis and cirrhosis. The aim of this study was to determine the diagnostic value of T1 and T2 mapping as well as extracellular volume fraction (ECV) for non-invasive assessment of liver fibrosis in AIH patients. Methods In this prospective study, 27 patients (age range: 19–77 years) with AIH underwent liver MRI. T1 and T2 relaxation times as well as ECV were quantified by mapping techniques. The presence of significant fibrosis (≥ F2) was defined as magnetic resonance elastography (MRE)-based liver stiffness ≥ 3.66 kPa. MRE was used as reference standard, against which the diagnostic performance of MRI-derived mapping parameters was tested. Diagnostic performance was compared by utilizing receiver-operating characteristic (ROC) analysis. Results MRE-based liver stiffness correlated with both, hepatic native T1 (r = 0.69; P
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