Noninvasive DW-MRI metrics for staging hepatic fibrosis and grading inflammatory activity in patients with chronic hepat
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HEPATOBILIARY
Noninvasive DW‑MRI metrics for staging hepatic fibrosis and grading inflammatory activity in patients with chronic hepatitis B Fangfang Fu1 · Xiaodong Li1 · Qiuyu Liu2 · Cuiyun Chen1 · Yan Bai1 · Dapeng Shi1 · Jia Sang3 · Kaiyu Wang4 · Meiyun Wang1 Received: 11 July 2020 / Revised: 21 September 2020 / Accepted: 29 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose To assess the value of various diffusion parameters obtained from monoexponential, biexponential, and stretchedexponential diffusion-weighted imaging (DWI) models for staging hepatic fibrosis (HF) and grading inflammatory activity in patients with chronic hepatitis B (CHB). Methods 82 patients with CHB and 30 healthy volunteers underwent DWI with 13 b-values on a 3T MRI unit. The standard apparent diffusion coefficient ( ADCst) was calculated using a monoexponential model. The true diffusion coefficient (Dt), pseudo-diffusion coefficient (Dp), and perfusion fraction (f) were calculated using a biexponential model. The distributed diffusion coefficient (DDC) and water-molecule diffusion heterogeneity index (α) were calculated using a stretched-exponential model. Receiver operating characteristic (ROC) curves were performed for diffusion parameters to compare the diagnosis performance. Results The distributions of hepatic fibrosis stages and the inflammatory activity grades (METAVIR scoring system) were as follows: F0, n = 1; F1, n = 16; F2, n = 31; F3, n = 19; and F4, n = 15. A0, n = 1; A1, n = 14; A2, n = 46; and A3, n = 21. ADCst, Dt and DDC values showed negative correlation with the fibrosis stage (r = − 0.418, − 0.717 and − 0.630, all P
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