Notch in Head and Neck Cancer
Head and neck cancer is a group of neoplastic diseases affecting the facial, oral, and neck region. It is one of the most common cancers worldwide with an aggressive, invasive evolution. Due to the heterogeneity of the tissues affected, it is particularly
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Notch in Head and Neck Cancer Cristina Porcheri and Thimios A. Mitsiadis
Abstract
Keywords
Head and neck cancer is a group of neoplastic diseases affecting the facial, oral, and neck region. It is one of the most common cancers worldwide with an aggressive, invasive evolution. Due to the heterogeneity of the tissues affected, it is particularly challenging to study the molecular mechanisms at the basis of these tumors, and to date we are still lacking accurate targets for prevention and therapy. The Notch signaling is involved in a variety of tumorigenic mechanisms, such as regulation of the tumor microenvironment, aberrant intercellular communication, and altered metabolism. Here, we provide an up- to-date review of the role of Notch in head and neck cancer and draw parallels with other types of solid tumors where the Notch pathway plays a crucial role in emergence, maintenance, and progression of the disease. We therefore give a perspective view on the importance of the pathway in neoplastic development in order to define future lines of research and novel therapeutic approaches.
Notch pathway · Oral epithelium · Oral mucosa · Epithelial Notch · Oral cancer · Carcinoma · Squamous cell carcinoma · Cell-to-cell interaction · Intercellular communication
C. Porcheri (*) · T. A. Mitsiadis Institute of Oral Biology, Orofacial Development and Regeneration, University of Zurich, Zurich, Switzerland e-mail: [email protected]
Abbreviations ADAM A disintegrin and metalloproteinase AKT Protein kinase B APC Adenomatous polyposis coli CAF Cancer-associated fibroblast CCL Chemokine (C-C motif) ligand CCND1 Cyclin D1 cK Cytokeratin COX2 Cyclooxygenase-2 CRC Colorectal cancer CSC Cancer stem cell CXCL CXC chemokine ligand CXCR CXC chemokine receptor DC Dendritic cells DLL Delta-like EGF(R) Epidermal growth factor (receptor) EMT E p i t h e l i a l - t o - m e s e n c h y m a l transition FBXW7 F-box and WD repeat domain containing 7 GSI DAPT Gamma-secretase inhibitors
© Springer Nature Switzerland AG 2021 J. Reichrath, S. Reichrath (eds.), Notch Signaling in Embryology and Cancer, Advances in Experimental Medicine and Biology 1287, https://doi.org/10.1007/978-3-030-55031-8_7
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Hairy and enhancer of split-1 Hairy/enhancer-of-split related with YRPW motif protein 1 HIF1 Hypoxia-inducible factor 1 HNCs Head and neck cancers HNSCC Head and neck squamous cell carcinoma HPV Human papillomavirus IL Interleukin ILC Innate lymphoid cell LAC Lung adenocarcinoma LNR Cysteine-rich Lin-12/Notch repeats LPS Lipopolysaccharide mAb Monoclonal antibody MALM Mastermind-like MET M e s e n c h y m a l - t o - e p i t h e l i a l transition MMP Matrix metalloproteinase MMTV Mouse mammary tumor virus NCR Natural cytotoxicity receptor NF-κB Nuclear factor kappa-light-chain- enhancer of activated B cells NICD Notch intracellular domain NK Natural killer cells NLS Nuclear localizing sequence Oct4 Octamer-binding transcription factor 4 OSCC Oral squamous cell carcinoma PTEN Phosphat
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