Novel Vapor Phase biodegradable coatings for controlled drug delivery systems
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1008-T08-26
Novel Vapor Phase biodegradable coatings for controlled drug delivery systems Arul Chakkaravarthi Arjunan1, Sushant Gupta2, Rajiv K Singh3, Deepika Singh4, and Jeff Opalko5 1 Sinmat Inc, 2153 SE Hawthorne Road (Box 2), Gainesville, FL, 32641 2 Materials Science and Engineering, University of Florida, 100 Rhines Hall, Gainesville, FL, 32607 3 Materials Science and Engineering, University of Florida, 100 Rhines Hall, Gainesville, FL, 32611 4 Sinmat Inc, 2153 SE Hawthorne Road (Box 2), Gainesville, FL, 32607 5 Sinmat Inc, 2153 SE Hawthorne Road, (Box 2), Gainesville, FL, 32607
ABSTRACT The synthesis of nano-functionalized drug particles or drug particles with nanoscale biodegradable polymeric coatings has wider ranging applications in sustained release drug delivery systems. An important area of application includes delivery of drugs, such as proteins, peptides, and glucocorticoids via the inhalation process. The advantages of this method include, rapid absorption by the body and lack of metabolic degradation effects which is typically by some drugs during oral delivery. Here we discuss the novel pulsed laser and pulsed electron method to synthesize nanoscale biodegradable coatings of poly lactic acid (PLA). A unique method for depositing the PLA films, pulsed electron beam deposition (PED) was used to deposit the films. This technique was tried done to overcome the difficulties like low absorption co-efficient of UV-laser. Method proved to be promising for producing smooth films and offers a better thickness control of the deposition. The roughness and other morphological characteristics of PED deposited films were superior over the conventional laser ablated films.
INTRODUCTION Polylactic acid (PLA) and Polyglycolic acid (PGA) are attractive biodegradable polymers due to various reasons. Though it can be used in various bio-applications, the most promising application is sustained drug delivery, such as proteins, peptides and glucocorticoids via inhalation process [1-5]. Most of the drug delivery systems use precise bio degradable polymer coatings that encapsulate the drug. Characterization of coating morphology and it correlations with mechanism of drug release is critical for the development and understanding of controlled drug deliver coatings [5]. Such coatings are done by mixing drug with polymer solution with air suspension technique, solvent coating method [4], dip coating or Physical vapor coating techniques like pulsed laser ablation. PLA has been studied extensively in this aspect and it biodegradation is known precisely at present[1,2,6-10]. The application of these bio-degradable polymers can be enhanced by using appropriate conformal coating techniques in which the coating thickness can be controlled in nanometers with high uniformity. Here we propose a novel vapor phase coating technique that helps in coating such polymers in drug delivery applications. Pulsed electron deposition (PED) has been promising alternative to pulsed laser ablation (PLD)
in the thin film coating applications [1
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