Numano type V Takayasu arteritis patients are more prone to have coronary artery involvement
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ORIGINAL ARTICLE
Numano type V Takayasu arteritis patients are more prone to have coronary artery involvement Taotao Li 1 & Juan Du 1 & Na Gao 1 & Xi Guo 2 & Lili Pan 1 Received: 28 February 2020 / Revised: 13 April 2020 / Accepted: 21 April 2020 # International League of Associations for Rheumatology (ILAR) 2020
Abstract Objectives Takayasu arteritis (TA) is a rare granulomatous vasculitis. Numano type V was the most frequently involved arteritis in China. In our study, we aimed to investigate the characteristics of the type V TA in Chinese people. Methods We retrospectively reviewed 143 medical charts of TA patients who were admitted to Beijing Anzhen Hospital from 2012 to 2019. All statistical studies were carried out with the SPSS program V.24.0. Results The duration of disease at first admission of type V TA patients was longer than non-type V group (110.6 (21.0, 168.0) vs. 69.1 (12.0, 120.0) months, P = 0.034). The incidences of hypertension and coronary artery involvement were more common in type V TA patients compared with non-type V patients (59.5% vs. 30.4%, P < 0.001; 33.8% vs. 17.4%, P = 0.025; respectively). The numbers of platelet (PLT) and the plateletcrit (PCT) in type V TA patients were significantly smaller than those in non-type V group (244.9 (190.5, 293.8) vs. 281.6 (214.5, 332.0) × 109/L, P = 0.005; 0.25 (0.20, 0.28) vs. 0.28 (0.22, 0.32) %, P = 0.003; respectively). Lesions located in the left anterior descending coronary (LAD) and the left circumflex coronary (LCX) presented more frequently in type V TA patients than in non-type V patients (LAD 76.0 vs. 41.7%, P = 0.041; LCX 56.0 vs. 8.3%, P = 0.006; respectively). Conclusions Type V TA patients had longer disease duration and higher incidence of hypertension and were more prone to have coronary artery involvement compared with non-type V patients. Key Points • This study is the first to assess characteristics of the type V TA in Chinese people. • Type V TA patients had longer disease duration and higher incidence of hypertension and were more prone to have coronary artery involvement compared with non-type V patients. • The numbers of platelet (PLT) and the plateletcrit (PCT) in type V TA patients were significantly smaller than those in non-type V group.
Keywords Coronary artery involvement . Hypertension . Takayasu arteritis . Type V
Introduction Takayasu arteritis (TA) is a rare, chronic, granulomatous vasculitis predominantly affecting the aorta and its main branches, pulmonary arteries and coronary arteries [1]. The inflammatory response in vessel walls eventually leads to
* Lili Pan [email protected] 1
Department of Rheumatology, Capital Medical University Affiliated Anzhen Hospital, 2 Anzhen Road, Chaoyang District, Beijing, China
2
Department of Interventional Radiology, Capital Medical University Affiliated Anzhen Hospital, 2 Anzhen Road, Chaoyang District, Beijing, China
stenosis, occlusion, dilation, or aneurysm formation of the involved vessels [2, 3]. The clinical symptoms of large vessel vasculitis are mainly due t
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