Numerical density of oligodendrocytes and oligodendrocyte clusters in the anterior putamen in major psychiatric disorder
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ORIGINAL PAPER
Numerical density of oligodendrocytes and oligodendrocyte clusters in the anterior putamen in major psychiatric disorders Natalya S. Kolomeets1 · Natalya A. Uranova1 Received: 16 October 2019 / Accepted: 3 February 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract There is increasing evidence to support the notion that oligodendrocyte and myelin abnormalities may contribute to the functional dysconnectivity found in the major psychiatric disorders. The putamen, which is an important hub in the cortico–striato–thalamo–cortical loop, has been implicated in a broad spectrum of psychiatric illnesses and is a central target of their treatments. Previously we reported a reduction in the numerical density of oligodendrocytes and oligodendrocyte clusters in the prefrontal and parietal cortex in schizophrenia. Oligodendrocyte clusters contain oligodendrocyte progenitors and are involved in functionally dependent myelination. We measured the numerical density (Nv) of oligodendrocytes and oligodendrocyte clusters in the putamen in schizophrenia, bipolar disorder (BPD) and major depressive disorder (MDD) as compared to healthy controls (15 cases per group). Optical disector was used to estimate the Nv of oligodendrocytes and oligodendrocyte clusters. A significant reduction in both the Nv of oligodendrocytes (− 34%; p
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