Occupational Asthma

Recent developments in the field of occupational asthma research and clinical practice are the topic of this volume. The contribution of occupational exposures to chemical and biological agents to the burden of asthma in adults is clearly described in an

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Progress in Inflammation Research

Series Editor Prof. Michael J. Parnham, PhD Director of Science MediMlijeko d.o.o. 10000 Zagreb Croatia

Advisory Board G. Z. Feuerstein (Wyeth Research, Collegeville, PA, USA) M. Pairet (Boehringer Ingelheim Pharma KG, Biberach a. d. Riss, Germany) W. van Eden (Universiteit Utrecht, Utrecht, The Netherlands)

Forthcoming titles: Inflammatory Cardiomyopathy (DCMi) – Pathogenesis and Therapy, H.-P. Schultheiß, M. Noutsias (Editors), 2010 Endothelial Dysfunction and Inflammation, A. Karsan, S. Dauphinee (Editors), 2010 Muscle, Fat and Inflammation: Sustaining a Healthy Body Composition, S.A. Stimpson, B. Han, A.N. Billin (Editors), 2011 The Inflammasomes, I. Couillin, V. Petrilli, F. Martinon (Editors), 2011 (Already published titles see last page.)

Occupational Asthma

Torben Sigsgaard Dick Heederik Editors

Birkhäuser

Editors Torben Sigsgaard School of Public Health Dept. of Environmental and Occupational Medicine Aarhus University Bartholin Allé 2 8000 Århus C Denmark

Dick Heederik Institute for Risk Assessment Sciences Division of Environmental and Occupational Health Utrecht University Yalelaan 2 3508 TD Utrecht Netherlands

Library of Congress Control Number: 2009943448

Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the internet at http://dnb.ddb.de

ISBN 978-3-7643-8555-2 The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use. This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained. © 2010 Birkhäuser Basel / Springer Basel AG P.O. Box 133, CH-4010 Basel, Switzerland Part of Springer Science+Business Media Printed on acid-free paper produced from chlorine-free pulp. TCF d Cover design: Markus Etterich, Basel Cover illustration: see p. 192, with friendly permission by Dick Heederik Printed in Germany ISBN 978-3-7643-8555-2 987654321

e-ISBN 978-3-7643-8556-9 www.birkhauser.ch

Contents

List of contributors

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vii

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xi

Jean-Luc Malo and Anthony Newman-Taylor The history of research on asthma in the workplace – development, victories and perspectives . . . . . . . . . . . . . . . . . . . . . . . .