Optical properties and biointerface interactions of chitin
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Optical properties and biointerface interactions of chitin Andreea Irina Barzic1 · Raluca Marinica Albu1 Received: 20 February 2020 / Revised: 8 June 2020 / Accepted: 5 October 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract The investigation aimed to elucidate the solvent influence on the physicochemical properties of a biologically active compound, namely chitin. The higher reactivity and stability of chitin in N,N-dimethylacetamide revealed that this is a good solvent for processing optical films with biological activity. In visible range, chitin displayed a normal dispersion of refractive index, which is 1.592 at 589 nm. The use of Wemple and Didomenico model enabled the determination of several optical constants, such as single-oscillator energy for electronic transitions and the dispersion energy and refractive index at infinite wavelength. From the obtained data concerning the surface wettability, the interactions at the biointerface of chitin with blood, fibroblasts, and microorganisms were investigated. The spreading of these biological media on chitin showed that in most cases, the cohesive interaction overcomes the adhesion ones. This is most suitable for fabrication of biomedical instrumentation with antimicrobial properties. Keywords Biopolymer · Molecular modeling · Refractive index · Wettability · Biointerface
Introduction Chitin is a natural polymer that is made of glycosidic bonds in linear or branched fashion between 2 adjacent monosaccharides, 2-(acetylamino)-2-deoxy-d-glucose [1]. The structure of this polymer resembles to that of cellulose, but it has −NHCOCH3 instead of −OH group on each C-2, so the structural units are containing N-acetyl-D-glucosamines in β (1 → 4) linkage. As a result of acetyl, amino and hydroxyl groups in the main chain, chitin forms inter- and intramolecular hydrogen bonds, which are leading a highly aggregated and crystalline material. The macromolecular chains of chitin are arranged as extended ribbons that are closely * Andreea Irina Barzic [email protected] 1
Department of Physical Chemistry of Polymers, Petru Poni Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda, 700487 Iasi, Romania
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packed. The acetyl groups enable formation of stable H-bonds along the intersheet direction that are hard to break, so the association with certain type of solvents is restricted [2]. Therefore, chitin is known to be insoluble in most used solvents for polymer processing, such as water, organic solvents, mild acidic or basic liquids, and so on [2–4]. The insolubility and intractability of this aminopolysaccharide has a negative impact on the scaling up of the processes for the preparation of chitin-based products [5, 6]. However, there has been revealed a small number of solvent systems which can be grouped in 3 categories: aqueous solutions of neutral salts, acid solvents, and organic solvents [4]. The first investigation concerning the solubility of chitin was done by Austin [3]. Sever
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