Oral water ingestion in the treatment of shock patients: a prospective randomized study
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LETTER
Oral water ingestion in the treatment of shock patients: a prospective randomized study Pierre‑Grégoire Guinot1,2* , Maxime Nguyen1,2, Valerian Duclos1, Agnes Soudry‑Faure3 and Belaid Bouhemad1,2 on behalf of The Water Study Group © 2020 Springer-Verlag GmbH Germany, part of Springer Nature
Dear Editor, While the cardiovascular effect of intravenous saline has been investigated in shock patients, the cardiovascular effects of oral water are unknown [1]. Oral resuscitation can improve cardiac output (CO) and blood pressure, thus outcomes of burn and septic patients [2–4]. We do not have data in shock patients. This study was designed to assess the effect of oral water on stroke volume (SV), blood pressure and tissue perfusion parameters in shock patients. After IRB approval and written consent, a prospective, open-label, randomized, controlled, parallel-arm, monocentric clinical trial was conducted at the anesthesia and critical care department of the Dijon University Hospital (France). Patients were randomized 1:1 to an intervention (500 ml via nasogastric tube over 15 min of water, Cristaline™) or standard care group (500 ml of intravenous saline solution over 15 min). The main outcome was the SV change (%) between baseline and immediately after the end of fluid expansion. The secondary outcomes were the changes of arterial blood pressure, CO, gap CO2/oxygen arteriovenous difference ratio, oxygen delivery, oxygen consumption, and arterial lactate. The study protocol (inclusion/exclusion criteria, ICU management, measurements, statistical analysis) is described *Correspondence: [email protected] 1 Anaesthesiology and Critical Care Department, Dijon Bourgogne University Hospital, 2 Bd Maréchal de Lattre de Tassigny, 21000 Dijon, France Full author information is available at the end of the article
The members of the Water Study Group are listed in “Acknowledgements”.
in the supplementary file. Data were expressed as median [interquartile range] or number (percentages). Mann– Whitney or Wilcoxon test were used. The threshold for statistical significance was set at p
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