Orally Administered Cinnamon Extract Attenuates Cognitive and Neuronal Deficits Following Traumatic Brain Injury
- PDF / 916,032 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 65 Downloads / 175 Views
Orally Administered Cinnamon Extract Attenuates Cognitive and Neuronal Deficits Following Traumatic Brain Injury Doaa Qubty 1
&
Vardit Rubovitch 1 & Tali Benromano 1 & Michael Ovadia 2 & Chaim G. Pick 1,3,4,5
Received: 12 July 2020 / Accepted: 14 August 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract The present paper shows how cinnamon extract (CE) consumption mitigates neuronal loss and memory impairment following traumatic brain injury (TBI), one of the world’s most common neurodegenerative diseases. TBI patients suffer short- and longterm behavioral, cognitive, and emotional impairments, including difficulties in concentration, memory loss, and depression. Research shows that CE application can mitigate cognitive and behavioral impairments in animal models for Alzheimer’s and Parkinson’s disease, whose pathophysiology is similar to that of TBI. This study builds on prior research by showing similar results in TBI mice models. After drinking CE for a week, mice were injured using our 70-g weight drop TBI device. For 2 weeks thereafter, the mice continued drinking CE alongside standard lab nutrition. Subsequently, the mice underwent behavioral tests to assess their memory, motor activity, and anxiety. The mice brains were harvested for immunohistochemistry staining to evaluate overall neuronal survival. Our results show that CE consumption almost completely mitigates memory impairment and decreases neuronal loss after TBI. Mice that did not consume CE demonstrated impaired memory. Our results also show that CE consumption attenuated neuronal loss in the temporal cortex and the dentate gyrus. Mice that did not consume CE suffered a significant neuronal loss. There were no significant differences in anxiety levels and motor activity between all groups. These findings show a new therapeutic approach to improve cognitive function and decrease memory loss after TBI. Keywords Traumatic brain injury (TBI) . Cognitive impairments . Cinnamon extract (CE) . Neurodegenerative disease . Neuronal survival . Spatial memory . Visual memory
Introduction Traumatic brain injury (TBI) is the leading cause of death and long-term disability in the world. It affects a significant part of the population and is considered the most common neurological disorder among people under 50 years of age (McAllister 2011; Slemmer et al. 2008). TBI is caused mainly when the head is impacted by force. It is often associated with falls, particularly among the elderly, injuries due to sports activity, and military
* Chaim G. Pick [email protected] 1
Department of Anatomy and Anthropology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
2
Department of Zoology, Tel Aviv University, Tel Aviv, Israel
3
The Dr. Miriam and Sheldon G. Adelson Chair and Center for the Biology of Addictive Diseases, Tel-Aviv University, Tel-Aviv, Israel
4
Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel
5
Sylvan Adams Sports Institute, Tel Aviv University, Tel Aviv, Israel
operations a
Data Loading...
