Organic Nitrates
Nitroglycerin and other organic nitrates have been used for over a century in the treatment of angina pectoris. Millions of patients, throughout the world, have placed nitroglycerin tablets under the tongue and have experienced rapid and dramatic relief f
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H erausgeber
Editorial Board
G. V. R. Born, Cambridge· O. Eichler, Heidelberg A. Farah, Rensselaer, NY . H. Herken, Berlin A. D. Welch, Princeton, NJ Beirat
Advisory Board E.l.Ariens· Z.M.Bacq· P.Calabresi· S.Ebashi· E.G.Erdos V.Erspamer· U.S. von Euler· W.S.Feldberg· G.B.Koelle· O.Krayer T.A.Loomis· H.Raskova· M.Rocha e Silva· F.Sakai· l.R. Vane P. G. Waser . W. Wilbrandt
Organic Nitrates Contributors
w. S. Aronow·
M. G. Bogaert . C. J. Carr G.R.Heyndrickx· E.M.Johnson,Jr.· J.C.Krantz,Jr. P. Needleman· B. Pitt· S. F. Vatner
Editor
Philip Needleman With 51 Figures
Springer-Verlag Berlin Heidelberg New York 1975
PHILIP NEEDLEMAN, Ph. D., Associate Professor of Pharmacology, Pharmacology Department, Washington University, 4566 Scott Avenue, S1. Louis, MO 63110jUSA
ISBN-13: 978-3-642-66026-9 DOl: 10.1 007/978-3-642-66024-5
e-ISBN-13: 978-3-642-66024-5
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© by Springer-Verlag Berlin· Heidelberg 1975. Softcover reprint ofthe hardcover 1st edition 1975 Library of Congress Cataloging in Publication Data Main entry under title: Organic nitrates. (Handbook of experimental pharmacology. New series; 40) 1. Nitrates-Physiological effect. 2. Nitrates. I. Aronow,W.S. II. Needleman, Philip, 1939- ed. III. Series: Handbuch der experimentellen Pharmakologie. New series; 40. [DNLM: 1. Glyceryl trinitrate. 2. Nitrates. 3. Nitrites. QV34 H236 new ser. v. 40J QP905.H3 Bd.40 [QP913.NIJ 615'.1'08, [574.1'924J 74-30332. The use of general descriptive names, trade marks, etc. in this publication, even if the former are not especially identified, is not be taken as a sign that such names as understood by the Trade Marks and Merchandise Marks Act, may accordingly be used freely by anyone.
Preface
Nitroglycerin and other organic nitrates have been used for over a century in the treatment of angina pectoris. Millions of patients, throughout the world, have placed nitroglycerin tablets under the tongue and have experienced rapid and dramatic relief from the chest pain that frequently occurs as a manifestation of disease of the coronary arteries. The empirical observation of the safe use of nitrates for tile alleviation of the symptoms of angina have led to their widespread medical acceptance. The use of organic nitrates preceded any knowledge of their mechanism of action or their ultimate metabolic fate. Thus, more simply stated, although sublingual nitrates helped the patients, little was known concerning what these drugs do to the body or what the body does to the drugs. A substantial number of investigators have focused on these questions especially durin
