Oscillatory potentials in patients with birdshot chorioretinopathy
- PDF / 1,373,402 Bytes
- 13 Pages / 547.087 x 737.008 pts Page_size
- 87 Downloads / 184 Views
(0123456789().,-volV) ( 01234567 89().,-volV)
ORIGINAL RESEARCH ARTICLE
Oscillatory potentials in patients with birdshot chorioretinopathy Diane Wang . Archana Nair . Naomi Goldberg . Alan Friedman . Douglas Jabs . Scott E. Brodie
Received: 8 July 2019 / Accepted: 3 June 2020 Ó Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose The electroretinogram (ERG) has proven to be useful in the evaluation and monitoring of patients with posterior uveitis. ERG oscillatory potentials (OPs) are sometimes reduced in many uveitic eyes with otherwise grossly normal ERG responses. This study compares ERG parameters, including OPs, between patients with birdshot chorioretinopathy, other posterior uveitis, and controls. Methods This was a retrospective case–control study. Sixty-four patients seen at a clinical practice had a total of 93 visits during which ERG was performed on both eyes. ERG data from 93 agematched controls were also collected. Root-meansquared (RMS) energy of the OPs was calculated using D. Wang A. Nair S. E. Brodie (&) Department of Ophthalmology, NYU Langone Eye Center, NYU Langone Health, 222 East 41st St, New York, NY, USA e-mail: [email protected] N. Goldberg Department of Ophthalmology, Manhattan Eye, Ear and Throat Hospital, New York, NY, USA A. Friedman Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, USA D. Jabs Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
Fourier analysis for 88 patients and 88 age-matched controls for whom complete data were available. Photopic flicker amplitudes, photopic flicker latencies, scotopic b-wave amplitudes, and OP RMS values were compared between patients and controls. Diagnostic performance was assessed using receiver operating characteristic (ROC) curves. Results The mean ages of patients and controls were 55.9 ± 10.8 (SD) years and 55.1 ± 11.5, respectively. 83% of the patients had a diagnosis of BCR. The mean OP RMS value was significantly different in patients (15.6 lV ± 9.7 lV) versus control eyes (33.0 lV ± 12.7 lV), p \ 0.001. Area under the ROC curves (AUROC) was 0.75 for photopic flicker amplitudes, 0.77 for photopic flicker latencies, 0.72 for scotopic b-wave amplitudes, and 0.88 for OP RMS. AUROC was significantly different between OP RMS and photopic flicker amplitudes (p \ 0.001), between OP RMS and flicker latencies (p = 0.0032), and between OP RMS and scotopic b-wave amplitudes (p \ 0.0001). Conclusion Analysis of OPs shows greater sensitivity and specificity in the diagnosis and evaluation of patients with birdshot chorioretinopathy than photopic and scotopic ERG amplitudes and photopic flicker latencies. Keywords ERG Oscillatory potentials Birdshot chorioretinopathy Posterior uveitis Fourier analysis
123
Doc Ophthalmol
Introduction Electroretinography is widely used in the diagnosis and monitoring of ocular disease [1]. It is an objective test that can detect abnormalities even in the absence of findings on fund
Data Loading...
