Outpatient Yttrium-90 microsphere radioembolization: assessment of radiation safety and quantification of post-treatment
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ONCOLOGY IMAGING
Outpatient Yttrium‑90 microsphere radioembolization: assessment of radiation safety and quantification of post‑treatment adverse events causing hospitalization Susanne Aberle1 · David Kenkel3 · Anton S. Becker3 · Gilbert Puippe3 · Irene Burger2 · Niklaus Schaefer4 · Thomas Pfammatter3 Received: 5 February 2019 / Accepted: 23 March 2020 © Italian Society of Medical Radiology 2020
Abstract Purpose Quantification of post-interventional adverse events of outpatient SIRT leading to hospitalization and quantification of radiation exposure. Materials and methods In this single-center, retrospective cohort study, we reviewed 212 patients treated with SIRT (90Y-microspheres) for primary and secondary liver malignancies. We searched for adverse events (AEs) and serious adverse events (SAEs), defined as AE’s causing hospitalization. Additionally, radiation exposure was measured in 36 patients. Results Seven patients had an SAE (3.3%), four patients had AE without readmission/hospitalization (1.9%) and 201 patients had no complications (94.8%). The mean ambient dose rate at 1 m distance from the source after administration of 90Y-microspheres was 1.88 µSv/h ± 0.74 (± SD) with a range from 4.3 to 0.2 µSv/h. Conclusion Outpatient radioembolization with 90Y-microspheres is safe and requires hospitalization only in a very small number of patients. The mean dose rate was low and met the national conditions for outpatient treatment ( 24 h) in four patients and not ongoing (i.e.,
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