Overexpression of ODF1 in Gastrointestinal Tract Neuroendocrine Neoplasms: a Novel Potential Immunohistochemical Biomark
- PDF / 2,142,509 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 36 Downloads / 162 Views
Overexpression of ODF1 in Gastrointestinal Tract Neuroendocrine Neoplasms: a Novel Potential Immunohistochemical Biomarker for Well-differentiated Neuroendocrine Tumors Baicheng Li 1 & Xinjun Li 1 & Ruiqi Mao 1 & Min Liu 2 & Limei Fu 1 & Lifang Shi 1 & Songlin Zhao 1 & Mingxia Fu 1 Accepted: 25 August 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Gastrointestinal tract neuroendocrine neoplasms (NENs) are a group of rare heterogeneous tumors with different prognoses. The 2019 WHO classification of digestive system tumors defines the classification of NENs as neuroendocrine tumors (NETs G1G3) and neuroendocrine carcinomas (NECs). We investigated outer dense fiber of sperm tails 1 (ODF1) expression in 137 gastrointestinal tract NENs including 53 NETs G1, 29 NETs G2, 3 NETs G3, and 52 NECs. Twenty adenocarcinomas and 6 squamous cell carcinomas also were included in the study. The results showed that ODF1 was positive in 83 of 85 (97.6%) primary gastrointestinal tract NETs, including 9 of 10 (90%) gastric, 19 of 19 (100%) small bowel, 10 of 11 (90.9%) colorectal, and 45 of 45 (100%) appendiceal neoplasms. There was a significantly statistical difference in the rates of ODF1 positivity in NETs (83/85, 97.6%) vs NECs (25/52, 48.1%, P < 0.001). ODF1 showed diffuse staining in NETs G1 (53/53, 100%) and NETs G2 (28/29, 96.6%), > 50% staining in NETs G3 (2/3, 66.7%), and focal staining (< 50%) in NECs (23/52, 44.2%) but 2 cases (2/52) showed > 50% staining. ODF1 showed no expression in all 20 adenocarcinomas and 6 squamous cell carcinomas. In conclusion, ODF1 was firstly identified as a novel marker for NENs, especially for NETs in the gastrointestinal tract. The expression mechanism and clinical significance of ODF1 in NENs needed further study. Keywords ODF1 . Neuroendocrine neoplasms . Gastrointestinal tract . Immunohistochemistry
Introduction Gastrointestinal tract neuroendocrine neoplasms (NENs) are a group of rare tumors, which can grow slowly or have aggressive biological behavior [1]. Then, accuracy of grading in NENs of the gastrointestinal tract is very important for oncologists, who need to decide whether to monitor by clinical observation or to begin aggressive therapy [2]. Morphology and grading are introduced into the classification of gastrointestinal tract NENs in the 2010 World Health Organization (WHO) classification [3]. The proliferation rate is the main determinant of NENs behavior, which defines NENs as either * Xinjun Li [email protected] 1
Department of Pathology, Binzhou People’s Hospital, No. 515 Huanghe 7th Road, Binzhou 256600, Shandong Province, People’s Republic of China
2
Department of Cardiology, Binzhou People’s Hospital, No. 515 Huanghe 7th Road, Binzhou 256600, Shandong Province, People’s Republic of China
well-differentiated low-grade (G1~G2) neuroendocrine tumors (NETs) or poorly differentiated high-grade (G3) neuroendocrine carcinomas (NECs). The 2019 WHO classification of digestive system tumors defines new groups of NET G3 with well-differenti
Data Loading...
