Ovulation Stimulation with Gonadotropins
How does one learn to stimulate ovulation? Often by oneself, when there is no opportunity to benefit from a mentor’s experience. But options abound regarding the evaluation strategy, protocol design, gonadotropin preparations, posology, treatment duration
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Ovulation Stimulation with Gonadotropins
Jean-Claude Emperaire
Ovulation Stimulation with Gonadotropins Foreword by Bruno Lunenfeld
Jean-Claude Emperaire Bordeaux France
This work is a translation from the book: Emperaire J.C., Pratique de la stimulation ovulatoire par les gonadotrophines, Springer-Verlag France, ISBN: 978-2-8178-0397-5, 2013 ISBN 978-3-319-18653-5 ISBN 978-3-319-18654-2 DOI 10.1007/978-3-319-18654-2
(eBook)
Library of Congress Control Number: 2015947362 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www. springer.com)
To my beloved wife Cosette and sons Pierre and Julien
Foreword
Gonadotropin therapy is so central to infertility treatment that it is easy to overlook the considerable discovery and research that preceded our understanding of the reproductive process, diagnostic procedures, treatment protocols, and the production of the effective and safe therapeutic agents available today. The history underpinning this development spans over 300 years and provides a splendid example of how basic animal experimentation and technological advances have progressed to clinical application. Following the discovery of germ cells in 1677, and the realization that fertilization involved the merging of two cell nuclei, one from the egg and one from sperm, in 1870, it took another 40 years to discover the interplay between the hypothalamus, pituitary, and gonads in 1910. The gonadotropins were discovered in 1927. Gonadotropins, such as pregnant mare serum gonadotropin (PMSG), were first introduced for ovarian stimulation in 1930. However, the use of PMSG led to antibody formation and had to be withdrawn. Following our discovery that urinary menopausal gonadotropins (HMG) could stimulate gonadal function in 1953, and the delivery o
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