Oxidative Stress and Free Radical Damage in Neurology
The role of free radicals and oxidative stress in neurological disorders has only recently been recognized, leaving clinical neurologists to seek in vain for information on the subject even in major textbooks. What published information there is may consi
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Editor-in-Chief Donald Armstrong
For other titles published in this series, go to http://www.springer.com/series/8145
Note from the Editor-in-Chief All books in this series illustrate point-of-care testing and critically evaluate the potential of antioxidant supplementation in various medical disorders associated with oxidative stress. Future volumes will be updated as warranted by emerging new technology, or from studies reporting clinical trials. Donald Armstrong Editor-in-Chief
Natan Gadoth
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Hans Hilmar Go¨bel
Editors
Oxidative Stress and Free Radical Damage in Neurology
Editors Natan Gadoth Sackler Faculty of Medicine Tel Aviv University Tel Aviv 69978, Israel and Department of Neurology Mayanei Hayeshua Medical Center Bnei-Brak 51544 [email protected]
Hans Hilmar Go¨bel Johannes Gutenberg University Medical Center Mainz, Germany [email protected]
ISBN 978-1-60327-513-2 e-ISBN 978-1-60327-514-9 DOI 10.1007/978-1-60327-514-9 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010937792 # Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface
The possible role of free radicals and oxidative stress in neurological disorders was not recognized until recently and thus is relatively unknown to practicing as well as academically minded clinical neurologists. This fact can be appreciated as one goes through the major textbooks recommended and used by residents in neurology looking, in vain, for information on this topic. One may find only short reminders of the possible association of superoxidase dismutase with familial amyotrophic lateral sclerosis and nitrous oxide with migraine. We may also find bits of information regarding the possible role of free radicals in the pathogenesis of traumatic brain injury. This limitation is not at all surprising, because the biological role of free radicals was discovered and scientifically accepted only recently. Denham Harman proposed the free radical theory of aging more than 50 years ago, but acceptance of this theory was slow until only a few years ago. During the late 1940s to early 1950s, retrolental fibroplasia in premature newborns was recognized as being caused by oxygen to
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