Oxidative Stress in Cancer Biology and Therapy
During the last 30 years it has become clearly evident that oxidative stress and free radical biology play key roles in carcinogenesis, cancer progression, cancer therapy, and normal tissue damage that limits treatment efficacy during cancer therapy. Thes
- PDF / 6,396,917 Bytes
- 464 Pages / 439.37 x 666.14 pts Page_size
- 35 Downloads / 253 Views
Editor-in-Chief Donald Armstrong
For further volumes: http://www.springer.com/series/8145
Note from the Editor-in-Chief All books in this series illustrate point-of-care testing and critically evaluate the potential of antioxidant supplementation in various medical disorders associated with oxidative stress. Future volumes will be updated as warranted by emerging new technology, or from studies reporting clinical trials. Donald Armstrong Editor-in-Chief
Douglas R. Spitz Kenneth J. Dornfeld Koyamangalath Krishnan David Gius ●
●
Editors
Oxidative Stress in Cancer Biology and Therapy
Editors Douglas R. Spitz, PhD Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa Iowa City, IA, USA [email protected] Koyamangalath Krishnan, MD Department of Internal Medicine East Tennessee State University Johnson City, TN, USA [email protected]
Kenneth J. Dornfeld, MD, PhD Duluth Clinic Radiation Oncology and Department of Biochemistry and Molecular Biology University of Minnesota Duluth, MN, USA [email protected] David Gius, MD, PhD Departments of Cancer Biology and Pediatrics and Radiation Oncology Vanderbilt Medical School Nashville, TN, USA [email protected]
ISBN 978-1-61779-396-7 e-ISBN 978-1-61779-397-4 DOI 10.1007/978-1-61779-397-4 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011940693 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface
Oxidative Stress and Cancer Biology: A Historical Perspective Driven by Warburg’s observation of increased glucose metabolism in cancer cells [1] as well as decades of research in the first three quarters of the twentieth century by Weber and many other investigators (reviewed in [2, 3]), cancer was thought to have at its origins fundamental defects in glycolytic and respiratory metabolism. This theoretical construct was based on the proposal that cancer cells had fundamental defects in their respiratory processes (O2 metabolism) that were believed to be compensated for by increases in glycolytic metabolism. This dependence on glycolysis was thought to keep cancer cells from being able to properly regulate the s
Data Loading...
