Oxytocin
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Uterine-rupture: 3 case reports In a descriptive study involving 1730 pregnant women identified retrospectively from the perinatal database of the Japan Society of Obstetrics and Gynecology (JSOG database) who underwent trial of labour after cesarean delivery (TOLAC) in Japan between January 2013 and December 2015, 3 women aged 30–38 years were described who developed uterine rupture following the administration of oxytocin for induction of labour during delivery [dosage, route, duration of treatment to reaction onsets and outcomes not stated]. Case 1: A 38-year-old woman, who had a history of one prior caesarean delivery, underwent TOLAC. During the procedure, she received oxytocin for induction of labour. At 40 weeks of gestation, she developed uterine rupture. Subsequently, she delivered a neonate via vaginal delivery with a birth weight of 3405g, an arterial cord blood pH of 7.20 and Apgar scores of 8 and 9 at one and five minutes, respectively. Additionally, she developed haemorrhage with a blood loss of 664mL. It was determined that oxytocin alone accounted for a higher proportion of uterine rupture. Case 2: A 37-year-old woman, who had a history of one prior caesarean delivery and one prior vaginal delivery, underwent TOLAC. During the procedure, she received oxytocin for induction of labour. At 37 weeks of gestation, she developed uterine rupture. Subsequently, she delivered a neonate via vaginal delivery with a birth weight of 2482g, an arterial cord blood pH of 7.26 and Apgar scores of 9 and 10 at one and five minutes, respectively. Additionally, she developed haemorrhage with a blood loss of 180mL. It was determined that oxytocin alone accounted for a higher proportion of uterine rupture. Case 3: A 30-year-old woman, who had a history of one prior caesarean delivery and one prior vaginal delivery, underwent TOLAC. During the procedure, she received oxytocin for induction of labour. At 37 weeks of gestation, she developed uterine rupture. Subsequently, she delivered a neonate via vaginal delivery with a birth weight of 3090g, an arterial cord blood pH of 7.40 and Apgar scores of 8 and 9 at one and five minutes, respectively. Additionally, she developed haemorrhage with a blood loss of 854mL. It was determined that oxytocin alone accounted for a higher proportion of uterine rupture. Takeya A, et al. Trial of labor after cesarean delivery (TOLAC) in Japan: rates and complications. Archives of Gynecology and Obstetrics 301: 995-1001, No. 4, Apr 2020. 803505129 Available from: URL: http://doi.org/10.1007/s00404-020-05492-8
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Reactions 3 Oct 2020 No. 1824
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